Effect of Protein Quality During Overreaching in Trained Cyclists
|ClinicalTrials.gov Identifier: NCT03994198|
Recruitment Status : Completed
First Posted : June 21, 2019
Last Update Posted : June 21, 2019
|Condition or disease||Intervention/treatment||Phase|
|Muscle Protein Synthesis||Dietary Supplement: Alpha-lactalbumin Dietary Supplement: Collagen peptides||Not Applicable|
Endurance-trained athletes frequently undergo periods of overreaching (increased training loads) to improve performance. In study 1, the investigators will determine whether 4-min and 20-min time trials are repeatable and whether they (individually or collectively) relate to 1-hour time trial performance. For Study 2, the investigators propose that proper nutrition (with a focus on the dose, timing, and quality of protein) can help mitigate the stress of overreaching, which will improve performance. Thus, the investigators will compare the effects of two diets that differ in terms of protein servings (dose, timing, quality). In Study 2, skeletal muscle biopsies will be collected to determine how dietary protein intervention impacts the quality and quantity of skeletal muscle mitochondria in response to intense training.
For study 1, the objective is to determine the reliability and validity of 4-min and 20-min time trial performance (mean power output).
For study 2, the objective is to (1) determine whether following an optimal protein diet during a period of intense training will, relative to a typical diet: (1) improve measures of exercise performance, (2) improve sleep quality, psychological wellbeing, and immune function, (3) improve the quality and quantity of skeletal muscle mitochondria.
Study 1 is a reliability and validity experiment designed to assess the key outcome measure in study 2.
Study 2 is a randomized, crossover study. Participants will, in a randomized order, complete both conditions, separated by a 4-day washout period.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||11 participants|
|Intervention Model:||Crossover Assignment|
|Intervention Model Description:||Randomized cross-over design|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Masking Description:||Participants and the investigators will be blinded the the supplement type, only the LPI will have the codes to decipher the supplement type. Supplements are referred to as A and B.|
|Official Title:||Monitoring Exercise Performance and Mitigating Training Stress in Endurance-trained Cyclists|
|Actual Study Start Date :||November 1, 2017|
|Actual Primary Completion Date :||April 1, 2018|
|Actual Study Completion Date :||August 30, 2018|
Participants will consume 60 g of alphalactalbumin (fraction of whey protein) for 3 training days.
Dietary Supplement: Alpha-lactalbumin
A protein fraction of whey protein, higher in tryptophan
Active Comparator: Collagen peptides
Participants will consume 60 g of collagen peptides for 3 training days.
Dietary Supplement: Collagen peptides
Collagen peptides from bovine sources
- Rate of myofibrillar muscle protein synthesis [ Time Frame: 12 days ]Rate of myofibrillar and protein synthesis (%/day)
- Rate of Sarcoplasmic muscle protein synthesis [ Time Frame: 12 days ]Rate of sarcoplasmic muscle protein synthesis (%/day)
- Plasma amino acids [ Time Frame: 1 x 1 hour ]Measurement of plasma amino acids 1 hour following ingestion of each beverage
- Sleep efficiency (%) [ Time Frame: 12 days ]Measured by Actigraphy
- Sleep fragmentation [ Time Frame: 12 days ]Measured by Actigraphy
- Wake after sleep onset (WASO) in minutes [ Time Frame: 12 days ]Measured by Actigraphy
- Total sleep time (min) [ Time Frame: 12 days ]Measured by Actigraphy
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03994198
|Ivor Wynne Centre|
|Hamilton, Ontario, Canada, L8S 4L8|
|Principal Investigator:||Stuart Phillips, PhD||McMaster University|