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Muscle Capillarization and Sarcopenia

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ClinicalTrials.gov Identifier: NCT03984994
Recruitment Status : Not yet recruiting
First Posted : June 13, 2019
Last Update Posted : June 13, 2019
Sponsor:
Collaborator:
University of Maryland, College Park
Information provided by (Responsible Party):
Steven J. Prior, Ph.D., University of Maryland, College Park

Brief Summary:
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders. This study is designed to determine whether increasing skeletal muscle capillarization through aerobic exercise will enhance muscular adaptations to strength training in older adults with sarcopenia.

Condition or disease Intervention/treatment Phase
Sarcopenia Other: Aerobic exercise training Other: Strength training Not Applicable

Detailed Description:
Sarcopenia, or the aging-related loss of muscle mass, affects a large number of older adults. The presence of sarcopenia is associated with physical disability, poor quality of life, and all-cause mortality, in part because sarcopenic adults have low muscle skeletal muscle capillarization and may lack the adequate perfusion needed to maintain muscle mass and function. This study will test the effects of increasing skeletal muscle capillarization through aerobic exercise training on responses to resistance training in older adults. Eligible participants will be randomized to one of two groups, resistance training preceded by aerobic exercise training (AEX-RT), or resistance training followed by aerobic exercise training (RT-AEX). Participants in the AEX-RT group will undergo 3 months of aerobic exercise training to increase skeletal muscle capillarization, followed by 3 months of resistance training. Participants in the RT-AEX group will undergo 3 months of resistance training, followed by 3 months of aerobic exercise training. Before and after the interventions, participants will undergo assessments of muscle size, strength, and capillarization, as well as assessments of physical function.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: The study employs 2 interventions: resistance training and aerobic exercise training. One group of participants will undergo resistance training then aerobic exercise training; the other group will undergo aerobic exercise training then resistance training.
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Increasing Muscle Capillarization to Enhance Responses to Strength Training in Sarcopenia
Estimated Study Start Date : October 2019
Estimated Primary Completion Date : September 2021
Estimated Study Completion Date : September 2022

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Aerobic exercise training followed by resistance training
Participants in this arm will undergo 3 months of aerobic exercise training, followed by 3 months of strength training
Other: Aerobic exercise training
3 months of center-based, supervised treadmill exercise

Other: Strength training
3 months of center-based, supervise strength training

Active Comparator: Resistance training followed by aerobic exercise training
Participants in this arm will undergo 3 months of strength training, followed by 3 months of aerobic exercise training
Other: Aerobic exercise training
3 months of center-based, supervised treadmill exercise

Other: Strength training
3 months of center-based, supervise strength training




Primary Outcome Measures :
  1. Skeletal muscle capillarization [ Time Frame: 6 months ]
    Change in the number of capillaries per unit of skeletal muscle tissue

  2. Muscle volume [ Time Frame: 6 months ]
    Change in the size of the thigh muscles


Secondary Outcome Measures :
  1. Skeletal muscle fiber size [ Time Frame: 6 months ]
    Change in the cross-sectional size of individual thigh skeletal muscle fibers

  2. Muscle strength [ Time Frame: 6 months ]
    Change in the strength/force produced by skeletal muscles of the thigh



Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 88 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Body Mass Index = 18-29.9 kg/m2
  • Non-smoker
  • Presence of at least moderate sarcopenia (low muscle mass per unit body height)

Exclusion Criteria:

  • Diagnosis of diabetes, cancer, pulmonary or renal disease
  • Physical impairment preventing exercise
  • Recent history of exercise training

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03984994


Contacts
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Contact: Steven J Prior, PhD 301-405-2483 sprior@umd.edu
Contact: Odessa Addison, PT, PhD 410-605-7000 ext 55393 oaddison@som.umaryland.edu

Sponsors and Collaborators
Baltimore VA Medical Center
University of Maryland, College Park

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Responsible Party: Steven J. Prior, Ph.D., Assistant Professor, University of Maryland, College Park
ClinicalTrials.gov Identifier: NCT03984994     History of Changes
Other Study ID Numbers: HP-00086001
First Posted: June 13, 2019    Key Record Dates
Last Update Posted: June 13, 2019
Last Verified: June 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Steven J. Prior, Ph.D., University of Maryland, College Park:
muscle
capillary
exercise

Additional relevant MeSH terms:
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Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms