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Effect of Emotion Mindsets on Emotion Processing

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ClinicalTrials.gov Identifier: NCT03978871
Recruitment Status : Enrolling by invitation
First Posted : June 7, 2019
Last Update Posted : June 7, 2019
Sponsor:
Collaborator:
Auburn University
Information provided by (Responsible Party):
University of Illinois at Urbana-Champaign

Brief Summary:
The guiding scientific premise for this research is that a growth emotion mindset will promote more adaptive emotion processing than a fixed emotion mindset. Because emotional sensitivity is particularly salient in adolescent girls, we will focus on this group. Using an experimental design, adolescent girls will be randomly assigned to either a mindset manipulation or a control group (brain education). Each group will complete a 25-minute computer-based lesson followed by a social stressor and a functional magnetic resonance imaging session. Two specific aims will be addressed: (1) to determine whether a growth mindset induction, relative to a control condition, predicts more adaptive emotion processing at the neural, behavioral, and psychological levels of processing; and (2) to determine whether neural processing of emotion accounts for the effect of a growth emotion mindset manipulation on behavioral and psychological processing of emotion. This study builds on a strong empirical database establishing the effect of mindsets on multiple domains of functioning but will be the first to examine the implications of a growth vs. fixed mindset about emotion for emotion processing in adolescent girls, thereby elucidating one specific youth attribute that can support or disrupt emotional development.

Condition or disease Intervention/treatment Phase
Emotions Behavioral: Growth Mindset Behavioral: Control Not Applicable

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 150 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Effect of Emotion Mindsets on Emotion Processing: A Multilevel Experimental Investigation
Actual Study Start Date : August 27, 2018
Estimated Primary Completion Date : June 30, 2021
Estimated Study Completion Date : October 30, 2021

Arm Intervention/treatment
Experimental: Growth Mindset
Persuasive education about emotions, brain development, and teenagers' ability to learn how to manage emotions
Behavioral: Growth Mindset
Growth emotion mindset induction

Active Comparator: Brain Education
Neutral education about functions of different parts of the brain
Behavioral: Control
Brain education




Primary Outcome Measures :
  1. Mean Change from Pre to Post Mindset Manipulation on Emotion Mindset Scale [ Time Frame: Pre vs. Post Mindset Manipulation: baseline ]
    Will compare mean change scores across the two conditions (mindset and control)

  2. Mean Change from Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale [ Time Frame: Pre vs. Post Mindset Manipulation: baseline ]
    Will compare mean change scores across the two conditions (mindset and control)

  3. Mean Change from Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes [ Time Frame: Pre vs. Post Mindset Manipulation: baseline ]
    Will compare mean change scores across the two conditions (mindset and control)

  4. Mean Difference in Performance on Go/nogo Task [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean performance as reflected in reaction time and accuracy across the two conditions (mindset and control)

  5. Mean Difference in Emotion Regulation Strategies [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean levels of self-reported emotion regulation strategies across the two conditions (mindset and control)

  6. Mean Difference in Amygdala Activation [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean levels of amygdala activation during relevant trials of the Social Evaluation Task and Go/no go Task across the two conditions (mindset and control)

  7. Mean Difference in Frontal Parietal Network-Amygdala Connectivity [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean levels of frontal parietal network-amygdala connectivity during relevant trials of the Social Evaluation Task and Go/no go Task across the two conditions (mindset and control)

  8. Mean Change on Self-Reported State Negative Affect [ Time Frame: Pre-Trier vs. Post-Trier: baseline ]
    Will compare mean change scores across the two conditions (mindset and control)


Secondary Outcome Measures :
  1. Mean Change from Baseline in Emotion Mindset Scores at 2 Months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  2. Mean Change from Baseline in Emotion Mindset Scores at 4 Months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  3. Mean Change from Baseline in Emotional Self-efficacy Scale Scores at 2 Months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  4. Mean Change from Baseline in Emotional Self-efficacy Scale Scores at 4 Months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  5. Mean Change from Baseline in Emotional Self-efficacy Vignettes Scores at 2 months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  6. Mean Change from Baseline in Emotional Self-efficacy Vignettes Scores at 4 months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  7. Mean Change from Baseline in Self-Reported Emotion Regulation Strategies Scores at 2 months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  8. Mean Change from Baseline in Self-Reported Emotion Regulation Strategies Scores at 4 months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  9. Mean Difference on Self-Reported State Negative Affect [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean scores during relevant trials of the Social Evaluation Task across the two conditions (mindset and control)


Other Outcome Measures:
  1. Mean Difference in Cingulo-Opercular Network Activation [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean levels of cingulo-opercular network activation during resting state and relevant trials of the Social Evaluation Task and Go/no go Task across the two conditions (mindset and control)

  2. Mean Difference in Cingulo-Opercular Network-Amygdala Connectivity [ Time Frame: Post Mindset Manipulation: baseline ]
    Will compare mean levels of cingulo-opercular network-amygdala connectivity during resting state and relevant trials of the Social Evaluation Task and Go/no go Task across the two conditions (mindset and control)

  3. Group Differences for Whole-Brain Analyses [ Time Frame: Post Mindset Manipulation: baseline ]
    Will conduct exploratory whole-brain analyses comparing activation patterns during resting state and relevant trials of the Social Evaluation Task and Go/no go Task across the two conditions (mindset and control)

  4. Mean Change from Baseline in Depressive Symptoms Scores at 2 months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  5. Mean Change from Baseline in Depressive Symptoms Scores at 4 months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  6. Mean Change from Baseline in Anxiety Symptoms Scores at 2 months [ Time Frame: At baseline and in approximately 2 months ]
    Will compare mean change scores across the two conditions (mindset and control)

  7. Mean Change from Baseline in Anxiety Symptoms Scores at 4 months [ Time Frame: At baseline and in approximately 4 months ]
    Will compare mean change scores across the two conditions (mindset and control)



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Ages Eligible for Study:   13 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Identify as female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Female age 13-18 years old
  • Oversample (approximately 1/3 of sample) for score >= .75 SD on a screening measure of fixed mindset about emotion
  • English-speaking
  • Ability to independently complete tasks and measures

Exclusion Criteria:

  • History of surgery involving metal implants
  • Possible metal fragments in the eyes or other parts of body
  • Pacemaker
  • A history of claustrophobia
  • Braces
  • Weighing over 250 pounds
  • Pregnancy or possibility of being pregnant
  • Severe medical conditions (e.g., blind or deaf, head trauma)
  • Learning disability or other condition that interferes with ability to complete tasks

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03978871


Locations
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United States, Illinois
University of Illinois
Champaign, Illinois, United States, 61820
Sponsors and Collaborators
University of Illinois at Urbana-Champaign
Auburn University

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Responsible Party: University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier: NCT03978871     History of Changes
Other Study ID Numbers: 18021
First Posted: June 7, 2019    Key Record Dates
Last Update Posted: June 7, 2019
Last Verified: June 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by University of Illinois at Urbana-Champaign:
Brain
Functional Neuroimaging
Stress, Psychological
Emotions
Psychology, Developmental