Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics
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|ClinicalTrials.gov Identifier: NCT03964701|
Recruitment Status : Recruiting
First Posted : May 28, 2019
Last Update Posted : May 28, 2019
|Condition or disease||Intervention/treatment|
|End Stage Renal Disease Dialysis||Other: no intervention|
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis. Identification of peritoneal membrane functional status changes over time, at the same patient (cohort study), by metabolomics, aiming in personalized medicine best practice.
Identification of peritoneal membrane functional status changes over time in immature infants' peritoneal membrane.
Identification of early and accurate markers of peritoneal membrane dysfunction when membrane status is possibly reversible that could predict peritoneal patients at risk for future loss of ultrafiltration and dialysis adequacy of small molecules examined today be PET, KT/V and Cr/Cl (when membrane status is not reversible).
Improve PD survival in infants and children.
|Study Type :||Observational|
|Estimated Enrollment :||18 participants|
|Official Title:||Identification of Early Biomarkers of Peritoneal Membrane Dysfunction in Children on Peritoneal Dialysis Using Metabolomics Analysis|
|Actual Study Start Date :||April 22, 2019|
|Estimated Primary Completion Date :||April 22, 2020|
|Estimated Study Completion Date :||April 22, 2020|
- Other: no intervention
no interventional study
- Change of Peritoneal Equilibration test profile [ Time Frame: 1 year ]Peritoneal Equilibration test
- Loss of dialysis adequency [ Time Frame: 1 year ]KT/V
- Elevated creatinine [ Time Frame: 1 year ]Creatinine Clearence
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03964701
|Contact: Nikoleta Printzafirstname.lastname@example.org|
|Contact: Yiannis Ntotis||+302310892466|
|1st ACADEMIC PEDIATRIC DEPARTMENT||Recruiting|
|Thessaloniki, Greece, 546 36|
|Contact: Nikoleta Printza|
|Principal Investigator:||Nikoleta Printza||Aristotle University|