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Serum Ferritin and Hepicidin Concentration in Chronic Periodontitis Patients With T2DM

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03964428
Recruitment Status : Completed
First Posted : May 28, 2019
Last Update Posted : June 11, 2019
Sponsor:
Information provided by (Responsible Party):
Nayroz Abdel Fattah Mohamed Tarrad, Fayoum University

Brief Summary:
serum level of ferritin and hepicidin were evaluated in periodontitis patient with and without type 2 diabetes before and after non surgical periodontal treatment to clarify their in periodontal disease

Condition or disease
Periodontitis Type2 Diabetes

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Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Decreased Ferritin And Increased Hepcidin Serum Levels In Periodontitis Patients With Diabetes Mellitus Type 2. Controlled Before-And-After Study
Actual Study Start Date : September 1, 2018
Actual Primary Completion Date : January 30, 2019
Actual Study Completion Date : January 30, 2019

Resource links provided by the National Library of Medicine


Group/Cohort
periodontitis
periodontitis with T2DM
control



Primary Outcome Measures :
  1. ferritin concentration [ Time Frame: 0-3 months ]
    ng/ml

  2. hepicidin concentration [ Time Frame: 0-3 months ]
    ng/ml



Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
participants were collected from the Outpatient Clinic, Department of Oral Medicine, Periodontology and Diagnosis, and the restorative clinic for the control subjects, Faculty of Oral and Dental Medicine, fayoum University
Criteria

Inclusion Criteria:

  • patients with more than 30% of the sites had clinical attachment level (CAL) 3-4mm with T2DM
  • systemically healthy patients with more than 30% of the sites had clinical attachment level (CAL) 3-4mm
  • healthy subjects had clinically healthy gingiva with ≤ 3mm pocket probing depth (PPD), nearly zero plaque index (PI), gingival index (GI), zero CAL.

Exclusion Criteria:

  • (I) Pregnancy or lactation, (II) History of receiving professional periodontal treatment during the past 6 months; (III) Treatment with any type of medications and/ or antibiotics during the past 3 months and (IV) Current or former smokers.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03964428


Locations
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Egypt
Nayroz Abelfattah Tarrad
Cairo, Egypt
Sponsors and Collaborators
Fayoum University
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Responsible Party: Nayroz Abdel Fattah Mohamed Tarrad, lecturer, Fayoum University
ClinicalTrials.gov Identifier: NCT03964428    
Other Study ID Numbers: fayoum dentistry
First Posted: May 28, 2019    Key Record Dates
Last Update Posted: June 11, 2019
Last Verified: June 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Nayroz Abdel Fattah Mohamed Tarrad, Fayoum University:
periodontitis
ferritin
hepicidin
type 2 diabetes mellitus
non surgical perioontal therapy
Additional relevant MeSH terms:
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Periodontitis
Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases