Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery
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|ClinicalTrials.gov Identifier: NCT03958942|
Recruitment Status : Not yet recruiting
First Posted : May 22, 2019
Last Update Posted : May 23, 2019
|Condition or disease||Intervention/treatment||Phase|
|Postoperative Pain Inflammatory Response||Other: Ultrasound quadratus lumborum block with bupivacaine 25% Other: lumbar epideural block with bupivacaine 25%||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Bilateral Ultrasound Guided Quadratus Lumborum Block Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response Following Major Lower Abdominal Cancer Surgery|
|Estimated Study Start Date :||June 1, 2019|
|Estimated Primary Completion Date :||January 1, 2020|
|Estimated Study Completion Date :||March 1, 2020|
Active Comparator: quadratus lumborum block
received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA.
Other: Ultrasound quadratus lumborum block with bupivacaine 25%
echogenic needle will be inserted in-plane with the ultrasound beam in a posterior-to-anterior direction through the quadratus lumborum muscle until the ventral fascia of the muscle penetrated. At this point, the needle directed toward the fascial plan between the quadratus lumborum and the Psoas muscle
Active Comparator: lumbar epideural block
received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA.
Other: lumbar epideural block with bupivacaine 25%
lumbar epidural will be performed for patients in group II using a 16-gauge Touhy epidural needle by a median approach. The T12 - L1 or L1 - L2 interspaces will be chosen for the injection. The epidural space identified by the loss of resistance technique.
- postoperative pain [ Time Frame: first 24 hours postoperatively ]postoperative pain intensity.
- postoperative inflammatory response [ Time Frame: first 24 hours postoperatively ]inflammatory response represented by the levels of: interleukins 1,6, and tumor necrosis factor alpha
- side effects [ Time Frame: first 24 hours postoperatively ]sedation, nausea, vomiting, and respiratory depression
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03958942
|Contact: Ahmad M Abd El-Rahman, M.D.||firstname.lastname@example.org|