Defocus Induced Changes on Choroidal Thickness
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|ClinicalTrials.gov Identifier: NCT03954886|
Recruitment Status : Recruiting
First Posted : May 17, 2019
Last Update Posted : May 21, 2019
|Condition or disease||Intervention/treatment||Phase|
|Induced Defocus to the Retina||Device: Plus powered optical lens||Not Applicable|
The purpose of this study is to determine modifying factors inducing or protecting against the development or progression of myopia, or nearsightedness. Myopia has reached epidemic levels in urbanized countries, reaching up to 90% of the teenage and young adult population in urban Asia. Myopia represents a significant socioeconomic burden and poses a risk for associated ocular diseases such as retinal detachment, choroidal neovascularization, and glaucoma. The economic and public health burden of myopia are growing disproportionately to the population, spurring interest in the development of therapies to prevent occurrence or progression. Myopia generally occurs because the eye grows too long, with onset and progression occurring from about ages 6 to 20. Though much is known about factors that influence eye growth, the exact mechanisms by which they do so have not been elucidated.
The goals of this study are to assess the short-term (10-50 minutes) effects of different magnitudes of myopic and hyperopic optical defocus on the transient thickness of the choroid in children and adults, as well as to assess the recovery period. Choroidal thickness will be measured non-invasively following 10-50 minutes of monocular exposure to -5D to +5D of optical defocus induced by spectacle lenses. The hypothesis is that choroidal thickness will increase with increasing myopic defocus and decrease with increasing hyperopic defocus. The relationship between the magnitude of defocus and the magnitude and direction of choroidal thickness change will be assessed.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||45 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Defocus on Choroidal Thickness|
|Actual Study Start Date :||May 15, 2018|
|Estimated Primary Completion Date :||May 31, 2020|
|Estimated Study Completion Date :||May 31, 2021|
Experimental: Induced myopic defocus
Subjects will view a television through a lens that induces blur to the retina for one hour. Images of the eye will be captured every 10 minutes
Device: Plus powered optical lens
A plus powered optical lens will be placed in front of one eye.
- Choroidal thickness [ Time Frame: 1 hour ]Changes in choroidal thickness following induced myopic defocus
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03954886
|Contact: Lisa Ostrin, OD, PhDfirstname.lastname@example.org|
|United States, Texas|
|University of Houston College of Optometry||Recruiting|
|Houston, Texas, United States, 77004|
|Contact: Lisa Ostrin, OD, PhD 713-857-9983 email@example.com|