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Trial record 18 of 2499 for:    CARBON DIOXIDE

Correlation Between Changes in End-Tidal Carbon Dioxide and Stroke Volume Variation Detected by Electrical Cardiometry as A Predictor of Fluid Volume Responsiveness in Hemodynamically Unstable Patients in the Intensive Care

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ClinicalTrials.gov Identifier: NCT03932617
Recruitment Status : Recruiting
First Posted : May 1, 2019
Last Update Posted : August 7, 2019
Sponsor:
Information provided by (Responsible Party):
Ahmed Elbaiomy Abo-elkhier, Tanta University

Brief Summary:
This study will be conducted to assess the role of end-tidal carbon dioxide (PETCO2) monitoring to predict the fluid volume responsiveness in correlation with stroke volume variation detected by electrical cardiometry in patients with hemodynamic instability.

Condition or disease Intervention/treatment
End Tidal Carbon Dioxide Cardiometry Fluid Responsiveness Shock Device: end tidal carbon dioxide by capnography

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Correlation Between Changes in End-Tidal Carbon Dioxide and Stroke Volume Variation Detected by Electrical Cardiometry as A Predictor of Fluid Volume Responsiveness in Hemodynamically Unstable Patients in the Intensive Care
Actual Study Start Date : June 1, 2019
Estimated Primary Completion Date : May 1, 2020
Estimated Study Completion Date : May 20, 2020

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
fluid responders Device: end tidal carbon dioxide by capnography

Moreover, since PETCO2 is mainly determined by tissue CO2 production (VCO2), alveolar ventilation and CO, when stable metabolic conditions are assumed and minute ventilation is kept constant, acute changes in PETCO2 have been shown to correlate strongly with changes in CO.

Thus, PETCO2 has been suggested as a simple economic and noninvasive alternative for continuous assessment of CO in different shock states.


fluid non responders Device: end tidal carbon dioxide by capnography

Moreover, since PETCO2 is mainly determined by tissue CO2 production (VCO2), alveolar ventilation and CO, when stable metabolic conditions are assumed and minute ventilation is kept constant, acute changes in PETCO2 have been shown to correlate strongly with changes in CO.

Thus, PETCO2 has been suggested as a simple economic and noninvasive alternative for continuous assessment of CO in different shock states.





Primary Outcome Measures :
  1. Assessment of sensitivity and specificity of end tidal carbon dioxide monitoring in predicting fluid responsiveness in correlation with stoke volume variation detected by cardiometry [ Time Frame: 24 hour ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
Tanta University Hospital at surgical intensive care unit (SICU).
Criteria

Inclusion criteria:

  • Patients who will be 18 years or older.
  • Patients on mechanical ventilation in the intensive care.
  • Patients developing hypotension (MABP) <65 mmHg.

Exclusion Criteria:

  • Patients with organ/s failure at presentation.
  • Patients with deep venous thrombosis.
  • Patients with limb and pelvic fractures.
  • Pregnant patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03932617


Contacts
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Contact: Ahmed Elbaiomy Abo-elkhier +201023201206 mansurgeon@yahoo.com

Locations
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Egypt
Tanta University Hospitals Recruiting
Tanta, ElGharbiaa, Egypt
Contact: Ahmed Elbaiomy Abo-elkhier    +201023201206    mansurgeon@yahoo.com   
Sponsors and Collaborators
Tanta University

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Responsible Party: Ahmed Elbaiomy Abo-elkhier, Assistant lecturer, Tanta University
ClinicalTrials.gov Identifier: NCT03932617     History of Changes
Other Study ID Numbers: 32880/01/19
First Posted: May 1, 2019    Key Record Dates
Last Update Posted: August 7, 2019
Last Verified: August 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Supporting Materials: Study Protocol

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: Yes
Device Product Not Approved or Cleared by U.S. FDA: No