Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT03927638
Recruitment Status : Enrolling by invitation
First Posted : April 25, 2019
Last Update Posted : April 25, 2019
Sponsor:
Information provided by (Responsible Party):
Peter A. Hosick, Montclair State University

Brief Summary:
This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Condition or disease Intervention/treatment
Overweight and Obesity Behavioral: sit/stand

Detailed Description:
The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
Actual Study Start Date : November 11, 2018
Estimated Primary Completion Date : May 15, 2022
Estimated Study Completion Date : May 15, 2022

Group/Cohort Intervention/treatment
Normal Weight
Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.
Behavioral: sit/stand
Subjects will be asked to both sit and stand during a single trial.

Overweight/Obese
Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.
Behavioral: sit/stand
Subjects will be asked to both sit and stand during a single trial.




Primary Outcome Measures :
  1. Heart Rate [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.

  2. Systolic Blood Pressure (SBP) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.

  3. Diastolic Blood Pressure (DBP) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.

  4. Oxygen Consumption [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Oxygen consumption will be measured using indirect calorimetry.

  5. Carbon Dioxide Production [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Carbon Dioxide will be measured using indirect calorimetry.

  6. Ventilation [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Ventilation will be measured using indirect calorimetry.

  7. Respiratory Exchange Ration (RER) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.


Secondary Outcome Measures :
  1. Height [ Time Frame: 1 minute ]
    Standard stadiometer will be used to measure height in meters.

  2. Weight [ Time Frame: 1 minute ]
    Standard scale will be used to measure weight in kilograms.

  3. Body Mass Index (BMI) [ Time Frame: 1 minute ]
    Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.

  4. Body Composition [ Time Frame: Approximately 15 minutes ]
    Body composition will be measured using air displacement plethysmography.

  5. Total Peripheral Resistance (TPR) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.

  6. Stroke Volume [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.

  7. Cardiac Output (Q) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.

  8. Muscle Oxygen Saturation [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
Healthy subjects between the ages of 18 and 50 years.
Criteria

Inclusion Criteria:

  • healthy adult

Exclusion Criteria:

  • Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
  • Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
  • Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
  • Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
  • Are pregnant or trying to become pregnant.
  • Are not between 18 and 50 years of age.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03927638


Locations
Layout table for location information
United States, New Jersey
Montclair State University
Montclair, New Jersey, United States, 07043
Sponsors and Collaborators
Montclair State University

Layout table for additonal information
Responsible Party: Peter A. Hosick, Assistant Professor, Montclair State University
ClinicalTrials.gov Identifier: NCT03927638     History of Changes
Other Study ID Numbers: 17-18-861
First Posted: April 25, 2019    Key Record Dates
Last Update Posted: April 25, 2019
Last Verified: April 2019

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Layout table for MeSH terms
Overweight
Body Weight
Signs and Symptoms