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Prevalence of Sarcopenia Among Elderly Living in Care Facilities in Klang Valley, Malaysia

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ClinicalTrials.gov Identifier: NCT03903328
Recruitment Status : Completed
First Posted : April 4, 2019
Last Update Posted : April 4, 2019
Sponsor:
Information provided by (Responsible Party):
Pramod Divakara Shenoy, MPT, Universiti Tunku Abdul Rahman

Brief Summary:
The primary aim of this study was to investigate the prevalence of age-related progressive decline in muscle mass and strength (Sarcopenia) among Malaysian elderly residing in long-term care facilities. It is a very important condition to study as it is associated with high incidence of fall, hospitalization and mortality.

Condition or disease Intervention/treatment
Sarcopenia Sarcopenic Obesity Other: Sarcopenia assessment

Detailed Description:

Over the past few decades, one condition that prominently affects the muscular system, known as sarcopenia, has captured the attention of healthcare experts and researchers. Sarcopenia is a geriatric syndrome characterized by the involuntary, gradual and generalized deterioration of skeletal muscle mass and strength with advancing age. It is to be noted that while sarcopenia is predominantly a syndrome of the elderly, its development may also be observed in various conditions such as disuse, malnutrition and cachexia, all of which are not exclusive only to the elderly. As of now, there are still ongoing research on an international scale with regards to its epidemiology, risk factors, causative factors, adverse clinical complications, prevention and treatment.

Beginning in 1st of October, 2016, Centres for Disease Control and Prevention (CDC) has finally officialised an International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10- CM) code for sarcopenia after its final proposal since April 2015. This establishment has enabled comprehensible clinical guidelines for diagnosis and treatment of sarcopenia, as well as separate reporting and data collection for sarcopenia in the medical community.

In essence, sarcopenia appears to be one of the most important causes of functional impairment, physical disability and loss of independence in older adults and a prevalence study will help to estimate the deleterious effects of this condition on the elderly living in the care facility, who happen to be the less privileged group as compared to their counterparts dwelling in the community.


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Study Type : Observational
Actual Enrollment : 205 participants
Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
Official Title: A Preliminary Study of Prevalence of Sarcopenia Among Elderly Living in Care Facilities in Klang Valley, Malaysia
Actual Study Start Date : December 6, 2016
Actual Primary Completion Date : December 4, 2017
Actual Study Completion Date : December 4, 2017

Intervention Details:
  • Other: Sarcopenia assessment
    Sarcopenia assessment by measurement of Skeletal Muscle mass index, hand grip strength and usual gait speed for 5 meter distance, as per the guidelines of Asia Working group for Sarcopenia study, was carried out.
    Other Names:
    • Height and weight measurements
    • Skeletal muscle mass index
    • Hand grip strength
    • Gait speed


Primary Outcome Measures :
  1. Skeletal muscle mass [ Time Frame: 10 minutes ]
    The skeletal muscle mass was measured using a Research grade Segmental BioImpedance Analyser to help derive the skeletal muscle mass index (Appendicular skeletal muscle mass/square of height= kg/m2)

  2. Grip strength [ Time Frame: 1 minute to 10 minutes ]
    Measurement of muscle strength was done using a Jamar hydraulic handheld dynamometer, only one maximal effort was allowed. However, for erroneous performance another attempt was provided after 10 minutes of rest. The measure was recorded in Kgf.

  3. Gait speed [ Time Frame: less the 10 minutes on an average ]
    Usual gait speed was used as a measure of physical performance, where the subject was required to walk along a 5 meter straight path. Time recorded using a stopwatch and speed recorded in meters per second



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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Elderly living in long-term care facilities (Institutionalized elderly) in Klang valley. Only Seven facilities allowing access to the study subjects were studied
Criteria

Inclusion Criteria:

  • Currently residing in a long-term care facility
  • Ability to walk, with or without the use of any walking aid
  • Citizen of Malaysia

Exclusion Criteria:

  • Inability to stand for height, weight and gait speed assessments
  • Presence of cardiac pacemaker
  • Presence of artificial limbs / prosthesis / metal implants
  • Difficult or dangerous behaviours
  • Severe cardiac, pulmonary, or musculoskeletal disorders
  • Severe cognitive impairment or any disability that makes communication impossible
  • Presence of terminal illness
  • Co-morbidities associated with high risk of falls (e.g. Parkinson's disease or CVA) or that may directly influence affect gait speed

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03903328


Sponsors and Collaborators
Universiti Tunku Abdul Rahman
Investigators
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Principal Investigator: PRAMOD D SHENOY, MPT Universiti Tunku Abdul Rahman
Study Director: sook Fan Yap, FRCP (UK) Universiti Tunku Abdul Rahman

Publications:
Abridged Life Tables, Malaysia, 2012-2015. (2015). Department of Statistics Malaysia. Retrieved from: https://www.statistics.gov.my/index.php?r=column/pdfPrev&id=cWxzRWcvMTZrWFp4UStqQmp3MG9QZz09

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Responsible Party: Pramod Divakara Shenoy, MPT, Head of Department of Physiotherapy and Senior Lecturer, Universiti Tunku Abdul Rahman
ClinicalTrials.gov Identifier: NCT03903328     History of Changes
Other Study ID Numbers: U/SERC/77/2016
First Posted: April 4, 2019    Key Record Dates
Last Update Posted: April 4, 2019
Last Verified: April 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Pramod Divakara Shenoy, MPT, Universiti Tunku Abdul Rahman:
muscle strength
physical performance
Sarcopenia
Additional relevant MeSH terms:
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Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms