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Trial record 3 of 3 for:    herpes zoster oticus

Herpes Zoster: Risk Factors, Complications and Special Situations

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ClinicalTrials.gov Identifier: NCT03903237
Recruitment Status : Completed
First Posted : April 4, 2019
Last Update Posted : April 4, 2019
Sponsor:
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland

Brief Summary:
This retrospective analysis is to investigate patients` history and clinical presentation in Herpes Zoster (HZ), Zoster-related complications, post-Zoster neuralgia and Herpes Zoster management in order to improve the management of HZ patients, to refine HZ-vaccination strategies and elucidate cost factors of HZ in in the setting of a university hospital in Switzerland generally and in a dermatology department specifically.

Condition or disease Intervention/treatment
Herpes Zoster Other: retrospective chart review

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Study Type : Observational
Actual Enrollment : 355 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Herpes Zoster: Risk Factors, Complications and Special Situations- a Retrospective Analysis
Actual Study Start Date : December 20, 2018
Actual Primary Completion Date : February 28, 2019
Actual Study Completion Date : February 28, 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Shingles


Intervention Details:
  • Other: retrospective chart review
    retrospective report review of HZ patients treated between 2005 and 2018 in the Department of Dermatology at the University Hospital Basel


Primary Outcome Measures :
  1. Evaluation of patients` history [ Time Frame: single time point assessment at baseline ]
    Free text evaluation of patients` history (age, sex, comorbidities, immunosuppression, obesity, human immune deficiency Virus (HIV), profession, current medication, vaccinations, seasonal occurence of HZ, history of Varicella Zoster virus (VZV) infection

  2. Description of the clinical presentation of HZ [ Time Frame: single time point assessment at baseline ]
    Free text description of the clinical presentation of HZ (localisation, dermatomes affected), Zoster-related acute pain

  3. Evaluation of zoster-related complications [ Time Frame: single time point assessment at baseline ]
    Free text evaluation of zoster-related complications (ophthalmic zoster, generalised HZ, Ramsay-Hunt syndrome, zoster meningoencephalitis)

  4. Evaluation of the herpes zoster management [ Time Frame: single time point assessment at baseline ]
    Free text evaluation of the herpes zoster management (local (antiviral) treatment, systemic antiviral and other treatments, number of revisits, average treatment-related costs, hospitalisations (rate, duration)

  5. Assessment of post-zoster neuralgia [ Time Frame: single time point assessment at baseline ]
    Free text assessment of post-zoster neuralgia (annual incidence, treatment options used)

  6. Evaluation of zoster and pregnancy [ Time Frame: single time point assessment at baseline ]
    Free text evaluation of zoster and pregnancy (incidence, time of pregnancy, pregnancy outcomes and complications)



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
patients with HZ who were seen at University Hospital Basel between 2004-2018
Criteria

Inclusion Criteria:

  • Reports of patients with HZ at University Hospital Basel between 2004-2018

Exclusion Criteria:

  • rejection to use patient data

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03903237


Locations
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Switzerland
Department of Dermatology, University Hospital Basel
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
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Principal Investigator: Simon Müller, Dr. med Department of Dermatology, University Hospital Basel

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Responsible Party: University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT03903237     History of Changes
Other Study ID Numbers: 2018-02270; sp19Mueller2
First Posted: April 4, 2019    Key Record Dates
Last Update Posted: April 4, 2019
Last Verified: April 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University Hospital, Basel, Switzerland:
post-zoster neuralgia
Herpes Zoster-related complications
Additional relevant MeSH terms:
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Herpes Zoster
Varicella Zoster Virus Infection
Herpesviridae Infections
DNA Virus Infections
Virus Diseases