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Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects (I-TSPT-R)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03897855
Recruitment Status : Not yet recruiting
First Posted : April 1, 2019
Last Update Posted : April 2, 2019
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier de Niort

Brief Summary:

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.


Condition or disease Intervention/treatment Phase
Post-Traumatic Stress Disorder in Old Age Other: Post Traumatic Stress Disorder Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
Estimated Study Start Date : April 1, 2019
Estimated Primary Completion Date : April 15, 2019
Estimated Study Completion Date : April 1, 2020

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Patient (TSPT-R)
Post Traumatic Stress Disorder
Other: Post Traumatic Stress Disorder
The test "Think / No-Think"

Experimental: control
No Post Traumatic Stress Disorder
Other: Post Traumatic Stress Disorder
The test "Think / No-Think"




Primary Outcome Measures :
  1. Inhibition score measured by the Think / No-Think Test [ Time Frame: 1 month ]
    the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011



Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 85 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

-

Regarding the constitution of the group patient (TSPT-R):

  • Subjects 65 years of age or older
  • Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
  • The traumatic event must have taken place at the latest before 65 years
  • Affiliated person or beneficiary of a social security scheme.
  • Written consent before any examination required by research)

Regarding the constitution of the control group:

  • Subjects 65 years of age or older
  • No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
  • Affiliated person or beneficiary of a social security scheme.
  • Written consent before any examination required by the research).

Exclusion Criteria:

  • For both groups:
  • Acute or chronic cognitive impairment known
  • GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:

    • 22 if no diploma
    • 23 if certificate of study
    • 25 if patent
    • 26 if bin or more
    • Remove one point at each threshold if age> 80 years
  • Sensory or motor disorder preventing the passing of different tests
  • Psychotic disorder
  • Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
  • Disorder of the use of a moderate or severe substance (except tobacco).
  • Patients under guardianship or curatorship.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03897855


Contacts
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Contact: Dominique LEGER, Doctor + 33 549 783 797 dominique.leger@ch-niort.fr

Sponsors and Collaborators
Centre Hospitalier de Niort
Investigators
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Study Director: Dominique LEGER, Doctor Centre Hospitalier de Niort

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Responsible Party: Centre Hospitalier de Niort
ClinicalTrials.gov Identifier: NCT03897855    
Other Study ID Numbers: CH-NIORT-2018-02
First Posted: April 1, 2019    Key Record Dates
Last Update Posted: April 2, 2019
Last Verified: March 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Mental Disorders