Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients (DiVADH)
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|ClinicalTrials.gov Identifier: NCT03897790|
Recruitment Status : Withdrawn (CPP requalification)
First Posted : April 1, 2019
Last Update Posted : September 26, 2019
|Condition or disease||Intervention/treatment|
|Hypertensive Disease Elderly Vasopressors General Anesthesia||Other: Transcranial Doppler (DTC)|
General anesthesia induces a sympathetic block frequently leading to hypotension, especially in elderly and hypertensive patients. Currently, Phenylephrine (PE) and Norepinephrine (NE) are commonly used in clinical practice to address this arterial pressure drop. Their cardiovascular effects are not exactly the same, even though they both increase mean blood pressure.
Maintenance of mean arterial pressure is not the only hemodynamic goal during general anesthesia in the elderly. Cognitive disorders have been demonstrated during post-anesthetic awakening.
Cerebral hemodynamics is assessed by analyzing the speed of blood flow in the middle cerebral artery using transcranial Doppler (DTC). It measures the systolic and diastolic speed as well as the pulsatility index, which are predictive factors for lowering cerebral blood flow.
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients|
|Actual Study Start Date :||April 2, 2019|
|Actual Primary Completion Date :||April 2, 2019|
|Actual Study Completion Date :||April 2, 2019|
Patients under vasoconstrictor
Patients older than 65 years old and hypertensive, requiring vasoconstrictor (phenylephrine or Neosynephrine) during general anesthesia.
Other: Transcranial Doppler (DTC)
Evaluation of Vasoconstrictor Vasoreactivity with Transcranial Doppler
- Variation of the velocity of the middle cerebral artery with vasoconstrictors and during a modification of EtCO2. [ Time Frame: 48 hours ]Measurements from transcranial doppler velocity of the middle cerebral artery
- Variation of cardiac output with vasoconstrictors and during modification of EtCO2. [ Time Frame: 48 hours ]Measurements from non invasive device (ClearSight System) of the cardiac output. The ClearSight system quickly connects to the patient by wrapping an inflatable cuff around the finger. Then the system presents cardiac output clearly and simply on the monitor.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03897790
|Study Director:||Marc LAFFON, MD-PhD||Univsersity Hospital, Tours|