The Effect of Vitamin D on Fertility
|ClinicalTrials.gov Identifier: NCT03890458|
Recruitment Status : Completed
First Posted : March 26, 2019
Last Update Posted : March 26, 2019
Objective: To examine the effect of vitamin D supplements on the pregnancy and clinical pregnancy rate in embryo transfer cycles.
Design: Experimental study with a pre- and post-test. Setting: In Vitro Fertilization Center Patients: Its sample consisted of 118 women, 58 in the experimental group and 60 in the control group.
Intervention(s): At the beginning of the infertility treatment, the experimental group took vitamin D supplements, and the control group did not. Vitamin D supplementation for infertile women includes regulation of a diet rich in vitamin D, educational and motivational interviews about insolation, and taking vitamin D orally.
Main Outcome Measure(s): 25(OH)D and beta HCG levels
|Condition or disease||Intervention/treatment||Phase|
|Infertility Infertility, Female Vitamin D Deficiency Vitamin D3 Deficiency||Drug: DEVIT-3||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||118 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Supportive Care|
|Official Title:||Effects of Vitamin D Supplements on Pregnancy Outcomes in Embriyo Transfer Cycles|
|Actual Study Start Date :||May 1, 2017|
|Actual Primary Completion Date :||November 30, 2017|
|Actual Study Completion Date :||November 30, 2017|
The physicians gave the women in the experimental group vitamin D oral drops in an ampoule of 300,000 IU and a vial of 50,000 IU to take during the IVF treatment. Written and verbal information about how to take vitamin D was provided to the participants by the nurses. The women took 300,000 IU vitamin D orally for the first week. In the second week of the treatment, 50,000 IU vitamin D (15 drops/day) was used as maintenance dose until the pregnancy test day.
|No Intervention: Control|
- Blood Vitamin D level [ Time Frame: The 25 (OH)D levels of the experimental group women were tested on the second or third day of their menstrual cycle. (Pretest) ]The vitamin D blood test was measured by the level of 25(OH)D.
- Blood Vitamin D level [ Time Frame: The 25 (OH)D levels of the women were tested on the two weeks after embryo transfer. (Posttest) ]The vitamin D blood test was measured by the level of 25(OH)D.
- Biochemical pregnancy [ Time Frame: HCG levels of the women were evaluated on the two weeks after embryo transfer (Post test) ]The pregnancy test was measured level of HCG in the blood.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03890458
|Principal Investigator:||Gamze Teskereci||Akdeniz University|