Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring
|ClinicalTrials.gov Identifier: NCT03859726|
Recruitment Status : Completed
First Posted : March 1, 2019
Last Update Posted : July 27, 2020
|Condition or disease||Intervention/treatment|
|Sepsis||Diagnostic Test: NIRS Diagnostic Test: Sublingual microcirculation|
Fluid therapy for sepsis patients has always been a research hotspot. Early studies suggest that early goal-directed therapy (EGDT) can reduce mortality in patients with sepsis and septic shock, which is included in the guidelines. However, recent studies suggest that EGDT does not reduce mortality. This may be related to the fact that EGDT only pays attention to systemic circulation and neglects microcirculation.
In the past few decades, arterial blood pressure, blood lactic acid and other circulatory indicators have been the target of septic shock treatment, but normal systemic circulation does not mean normal tissue perfusion. Obstacles to tissue perfusion, oxygenation and microcirculation may still exist. At the same time, compared with systemic hemodynamic parameters, microcirculation parameters may play a stronger role in predicting the prognosis of sepsis patients. It is believed that the ideal goal of resuscitation therapy for sepsis should be based on whether microcirculation function has been restored or not.
Objective:to observe the success rate of microcirculation imaging and oxygen saturation of peripheral tissues in sepsis patients under the guidance of current guidelines and procedures. At the same time, we compared the predictive value of microcirculation indicators to the prognosis of septic shock patients.
|Study Type :||Observational|
|Actual Enrollment :||72 participants|
|Official Title:||Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation|
|Actual Study Start Date :||March 20, 2019|
|Actual Primary Completion Date :||March 31, 2019|
|Actual Study Completion Date :||March 31, 2020|
6hLC≥10% NIRS Sublingual microcirculation
Diagnostic Test: NIRS
Near-infrared spectroscopy (NIRS) offers non-invasive, in-vivo, real-time monitoring of tissue oxygenation. Changes in regional tissue oxygenation as detected by NIRS may reflect the delicate balance between oxygen delivery and consumption.
Diagnostic Test: Sublingual microcirculation
The sidestream dark field (SDF) imaging devices provide high contrast images of the microvasculature.
Non compliance group
- Sepsis Related Organ Failure Assessment [ Time Frame: 72 hours ]SOFA
- 28-day mortality [ Time Frame: 28-day ]mortality
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03859726
|Xiangya Hospital, Central South University|
|Changsha, Hunan, China, 410000|