Influence of Yogic Breathwork on CSF Circulation (CSF)
|ClinicalTrials.gov Identifier: NCT03858309|
Recruitment Status : Active, not recruiting
First Posted : February 28, 2019
Last Update Posted : March 4, 2020
|Condition or disease||Intervention/treatment||Phase|
|CSF Circulation||Behavioral: Breathing Group 1 Behavioral: Breathing Group 2||Not Applicable|
The purpose of this research protocol is to determine the influence of an 8-week breathing intervention on cerebrospinal fluid (CSF) circulation among healthy participants using a non-invasive real-time phase-contrast magnetic imaging (RT-PCMRI) technique. This aim will be examined by studying the changes in each participant's pre- and post-intervention CSF flow dynamics using the non-invasive RT-PCMRI technique during two MRI scans (one before and one after the 8-week intervention).
The study protocol consists of 20 healthy participants (two groups; 10 in each group with different breathing practices) undergoing an 8-week intervention, and pre-and post-intervention outcome measures.
The two 8-week interventions will be guided by two separate certified experienced yoga teachers. Both interventions will consist of 60-minute weekly group on-site sessions (1day/week) with a 20-minute daily home sessions (in between on-site sessions; 6 days/week) using home-aid practice materials. Participants' respiration data will be objectively tracked using a wearable respiration tracker device.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||26 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Quantifying the Influence of Yogic Breathwork on Cerebrospinal Fluid Circulation|
|Actual Study Start Date :||July 10, 2019|
|Actual Primary Completion Date :||November 25, 2019|
|Estimated Study Completion Date :||February 1, 2021|
Experimental: Breathing Group 1
Arm 1 will receive an 8-week intervention that consists of a set of breathing practices through 60-minute weekly group on-site sessions (1day/week) with a 20-minute daily home sessions (in between on-site sessions; 6 days/week).
Behavioral: Breathing Group 1
The 8-week breathwork intervention incorporates a set of breathing practices under the guidance of a certified yoga teacher.
Active Comparator: Breathing Group 2
Arm 2 will receive an 8-week intervention that consists of slow breathing practices through 60-minute weekly group on-site sessions (1day/week) with a 20-minute daily home sessions (in between on-site sessions; 6 days/week).
Behavioral: Breathing Group 2
The 8-week breathwork intervention incorporates a set of slow breathing practices under the guidance of a certified yoga teacher.
- CSF Flow Velocities [ Time Frame: Once before and after the 8-week intervention ]The changes in pre- and post- intervention CSF flow velocities will be measured using a non-invasive MRI approach.
- Systolic and Diastolic Blood Pressure [ Time Frame: Once before and once after the 8-week intervention ]The changes in pre- and post-intervention blood pressure will be measured.
- Body Mass Index (BMI) [ Time Frame: Once before and once after the 8-week intervention ]The changes in pre- and post-intervention BMI will be measured. The BMI is derived from each participant's height and weight information.
- Respiration [ Time Frame: Respiration data will be collected when participants are performing the breathing practices during the weekly on-site sessions (60-minute/week) and daily home practice (20-minute/day) over the course of 8-week intervention. ]Respiration phases will be measured using a wearable respiration tracker to objectively track respiration of participants throughout the interventions.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03858309
|United States, Oregon|
|Oregon Health & Science University|
|Portland, Oregon, United States, 97239|
|Principal Investigator:||Yildiz||Oregon Health and Science University|