Translational Control of Anabolic Resistance in Aging Muscle
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|ClinicalTrials.gov Identifier: NCT03839628|
Recruitment Status : Active, not recruiting
First Posted : February 15, 2019
Last Update Posted : February 27, 2020
|Condition or disease||Intervention/treatment||Phase|
|Physical Inactivity||Other: Reduced Physical Activity||Not Applicable|
Pre-testing- The baseline evaluation will assess muscle function and strength, and an oral glucose tolerance test. After the baseline visit, participants will be provided with a step activity monitor to track their level of activity. This will provide a baseline of the participant's normal level of physical activity so an accurate level of 75% activity reduction can be determined. A 3-day daily dietary diary will be provided for the participant to self-report prior to the experiment, as well.
Day 1- After the participant completes their normal activity log and dietary diary, they will be asked to return to the research center for a body composition scan and a metabolic study.
The metabolic study will involve blood sampling from an arm vein and muscle biopsies from the thigh before and after a leucine drink.
2-week period of inactivity- After the metabolic study, the participant will return home and maintain a reduced level of activity (75% reduction) for a two-week period. During this time, the participant will receive phone calls from research personnel in order to maintain adherence to the intervention.
Day 14- After the 2-week reduced activity period, the participant will return to the research center to receive a body composition scan and undergo a metabolic study identical to 'Day 1'.
Post-testing- After Day 14, the participant will be asked to return once again to the research center for a oral glucose tolerance test and the exercise lab for muscle function testing.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||8 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Participants will be tested before and 2-weeks after they have reduced their level of physical activity|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Translational Control of Anabolic Resistance in Aging Muscle|
|Actual Study Start Date :||March 5, 2019|
|Estimated Primary Completion Date :||December 17, 2020|
|Estimated Study Completion Date :||December 17, 2021|
Experimental: Reduced Physical Activity
Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity
Other: Reduced Physical Activity
Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Other Name: Muscle Disuse
- Lean Mass [ Time Frame: baseline and 2-weeks ]Change in lean mass
- Strength [ Time Frame: baseline and 2-weeks ]Change in muscle strength
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03839628
|United States, Utah|
|University of Utah|
|Salt Lake City, Utah, United States, 84112|
|Principal Investigator:||Micah Drummond||University of Utah|