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L-arginine Supplementation and Resistance Exercise

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03827005
Recruitment Status : Completed
First Posted : February 1, 2019
Last Update Posted : February 1, 2019
Sponsor:
Information provided by (Responsible Party):
Kyle Hackney, North Dakota State University

Brief Summary:
The purpose of this study was to examine the acute endothelial, cardiovascular, and performance responses to L-arginine by assessing flow-mediated dilation (FMD) and heart rate variability (HRV) both before and after resistance exercise to fatigue. Thirty (15 male, 15 female) physically active participants volunteered for a randomized, cross-over, double-blind, placebo- controlled clinical trial. Participants completed five sets of elbow extension-flexion exercise after consumption of either 3 g of placebo or 3 g L-arginine.

Condition or disease Intervention/treatment Phase
Healthy Adult Dietary Supplement: L-arginine Dietary Supplement: Placebo Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: double blind, placebo, controlled -cross over
Masking: Double (Participant, Investigator)
Masking Description: blinding performed by co-investigator not involved with data collection
Primary Purpose: Other
Official Title: The Acute Effects of L-arginine Supplementation on Flow-mediated Dilation After Resistance Exercise to Fatigue
Actual Study Start Date : July 16, 2016
Actual Primary Completion Date : April 30, 2017
Actual Study Completion Date : May 30, 2017

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Placebo Comparator: placebo
3 grams cornstarch once per day for one day.
Dietary Supplement: L-arginine
NOW Foods, Bloomingdale, IL

Dietary Supplement: Placebo
InHealth Specialty Pharmacy, Fargo, ND
Other Name: cornstarch

Experimental: L-arginine
3 g L-arginine once per day for one day.
Dietary Supplement: L-arginine
NOW Foods, Bloomingdale, IL

Dietary Supplement: Placebo
InHealth Specialty Pharmacy, Fargo, ND
Other Name: cornstarch




Primary Outcome Measures :
  1. Change in Flow mediated dilation 120 seconds post-cuff release [ Time Frame: Change from Baseline and 120 seconds ]
    Flow mediated dilation was measured using a A Philips HD11XE ultrasound system (Philips, Amsterdam, NL) equipped with 2D imaging, color and spectral Doppler, and a high-frequency vascular transducer.

  2. Change in Heart Rate Variability 10 minutes after intervention [ Time Frame: Change from Baseline and 10 minutes post-exercise ]
    Hear rate variability was recorded using a Polar H7 Bluetooth strap (Polar, Bethpage, NY) combined Personal Pro Elite HRV smartphone application (elitehrv.com) over 5 minutes intervals then further analyzed with Kubios software



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 25 Years   (Adult)
Sexes Eligible for Study:   All
Gender Based Eligibility:   Yes
Gender Eligibility Description:   self reported
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • generally healthy
  • physically active

Exclusion Criteria:

  • previous clinical trial
  • pregnancy
Publications:

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Responsible Party: Kyle Hackney, Assistant Professor, North Dakota State University
ClinicalTrials.gov Identifier: NCT03827005    
Other Study ID Numbers: HE16235
First Posted: February 1, 2019    Key Record Dates
Last Update Posted: February 1, 2019
Last Verified: January 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Kyle Hackney, North Dakota State University:
L-arginine
flow mediated dilation
resistance exercise