The CHYMASE Angiotensin-(1-12) Axis in Cardiovascular Disease
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|ClinicalTrials.gov Identifier: NCT03826745|
Recruitment Status : Recruiting
First Posted : February 1, 2019
Last Update Posted : September 12, 2019
|Condition or disease||Intervention/treatment|
|Cardiovascular Disease||Other: Plasma/Urine|
Study is to determine the presence of the human sequence on Ang-(1-12) in the plasma of normal male and female normotensive, hypertensive and/or resistant hypertensive subjects.
To measure concentrations of Ang-(1-12) in either serum or spot urine collections from male and female normal, hypertensive and/or resistant hypertensive subjects.
To assess whether chymase activity can be detected in human serum and urine using the radiolabeled amino acid sequence of 1251-Ang-(1-12)
|Study Type :||Observational|
|Estimated Enrollment :||75 participants|
|Official Title:||The CHYMASE Angiotensin-(1-12) Axis in Cardiovascular Disease|
|Actual Study Start Date :||February 11, 2019|
|Estimated Primary Completion Date :||December 31, 2019|
|Estimated Study Completion Date :||December 31, 2019|
- Other: Plasma/Urine
Plasma of normal male and female normotensive, hypertensive, and/or resistant hypertensive subjects.
- Presence of Ang-(1-12) in Human Plasma/Urine [ Time Frame: one day ]Determine the presence of the human sequence of Ang-(1-12) in the plasma of normal male and female normotensive, hypertensive and/or resistant hypertensive subjects.
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03826745
|Contact: Henry A Punzi, MDemail@example.com|
|Contact: Kathy Cassidy, RNfirstname.lastname@example.org|
|Principal Investigator:||Henry A Punzi, MD||Punzi Medical Center|