Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
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|ClinicalTrials.gov Identifier: NCT03821714|
Recruitment Status : Completed
First Posted : January 30, 2019
Last Update Posted : January 5, 2021
|Condition or disease||Intervention/treatment||Phase|
|Septic Shock||Drug: Glucocorticoid combination therapy Drug: Glucocorticoid||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock|
|Actual Study Start Date :||February 1, 2019|
|Actual Primary Completion Date :||January 1, 2020|
|Actual Study Completion Date :||January 30, 2020|
Experimental: Glucocorticoid combination therapy Group
Hydrocortisone 200mg continuous intravenous infusion(24h) combined with vitamin C1.5g intravenous infusion every 6 hours and vitamin B1 200mg intravenous infusion every 12 hours.
Drug: Glucocorticoid combination therapy
Glucocorticoid combination therapy is defined as the combination of hydrocortisone, vitamin C, and vitamin B1.
Other Name: Hydrocortisone, vitamin C and vitamin B1
Active Comparator: Glucocorticoid Group
Hydrocortisone 200mg continuous intravenous infusion(24h)
The glucocorticoid group was defined as the use of hydrocortisone alone.
Other Name: Hydrocortisone
- Perfused vessel density (PVD) [ Time Frame: 24 hours after treatment ]Determinant of capillary diffusive capacity
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03821714
|Nanjing Zhongda Hospital, Southeast University|
|Nanjing, Jiangsu, China, 210000|
|Principal Investigator:||Jingyuan Xu, PhD||Southeast University|