Rheumatoid Arthritis Disease Activity and Sub Clinical Atherosclerosis
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|ClinicalTrials.gov Identifier: NCT03821090|
Recruitment Status : Not yet recruiting
First Posted : January 29, 2019
Last Update Posted : February 15, 2019
RA is associated with traditional cerebrovascular risk factors as subclinical atherosclerosis.
Chronic inflammation and high disease activity are associated with atherosclerotic burden, higher incidence of cerebrovascular disease ,chronic heart failure , and mortality of patients with RA .
High-sensitivity cardiac troponin I (hs-cTnI) predicted a greater risk coronary heart disease, heart failure hospitalization and overall mortality in the general population .
So the aim of the study is to correlate between high sensitive cardiac troponin I and disease activity to the presence of subclinical atherosclerosis in RA patients
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||A Study in Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis|
|Estimated Study Start Date :||July 1, 2019|
|Estimated Primary Completion Date :||July 1, 2022|
|Estimated Study Completion Date :||December 1, 2022|
Eighty rheumatoid arthritis patients fulfilling American College of Rheumatology (ACR) 2010 classification criteria, all of them will be subjected to
6-Echocardiography 7-Carotid intima media thickness (cIMT)using carotid doppler 8-Venous blood will be withdrawn to do the following laboratory tests
fifty healthy subjects age and sex matched will be included , all of them will be subjected to
5-Echocardiography 6-Carotid intima media thickness (cIMT)using carotid doppler 8-Venous blood will be withdrawn to do the following laboratory tests
- detection of subclinical atherosclerosis in RA patients who have no cardiovascular risk factors [ Time Frame: baseline ]Correlation between high sensitive cardiac troponin I and TNF α as a pro inflammatory cytokine to the presence of subclinical atherosclerosis in RA patients who have no cardiovascular risk factors
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03821090
|Contact: Sabrin R Mahmoud, assistant firstname.lastname@example.org|