Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03820427 |
Recruitment Status :
Completed
First Posted : January 29, 2019
Last Update Posted : January 29, 2019
|
Sponsor:
Universitätsmedizin Mannheim
Information provided by (Responsible Party):
Dr. Frederik Trinkmann, Universitätsmedizin Mannheim
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Brief Summary:
Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.
Condition or disease | Intervention/treatment |
---|---|
Bronchial Asthma Pulmonary Healthy Controls | Diagnostic Test: impulse oscillometry Diagnostic Test: multiple breath washout test Diagnostic Test: body plethysmography |
Study Type : | Observational |
Actual Enrollment : | 147 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma |
Actual Study Start Date : | August 2015 |
Actual Primary Completion Date : | December 2018 |
Actual Study Completion Date : | December 2018 |
Group/Cohort | Intervention/treatment |
---|---|
bronchial asthma
Patients with known or suspected asthma.
|
Diagnostic Test: impulse oscillometry
impulse oscillometry Diagnostic Test: multiple breath washout test multiple breath washout test Diagnostic Test: body plethysmography body plethysmography |
pulmonary healthy controls
Patients without known or suspected pulmonary disease
|
Diagnostic Test: impulse oscillometry
impulse oscillometry Diagnostic Test: multiple breath washout test multiple breath washout test Diagnostic Test: body plethysmography body plethysmography |
Primary Outcome Measures :
- Global ventilation heterogeneity [ Time Frame: 30 minutes ]lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout
- Local ventilation heterogeneity [ Time Frame: 30 minutes ]Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout
Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Study Population
patients with indication for routine lung function testing
Criteria
Inclusion Criteria:
- known or suspected bronchial asthma
- known or suspected obstructive ventilation disorder
- pulmonary healthy controls
Exclusion Criteria:
- pregnancy
- inability to participate
No Contacts or Locations Provided
Responsible Party: | Dr. Frederik Trinkmann, Principal Investigator, Universitätsmedizin Mannheim |
ClinicalTrials.gov Identifier: | NCT03820427 |
Other Study ID Numbers: |
MBW-asthma |
First Posted: | January 29, 2019 Key Record Dates |
Last Update Posted: | January 29, 2019 |
Last Verified: | January 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Additional relevant MeSH terms:
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |