UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy (AV1451 ADC)
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|ClinicalTrials.gov Identifier: NCT03809351|
Recruitment Status : Not yet recruiting
First Posted : January 18, 2019
Last Update Posted : September 24, 2019
|Condition or disease||Intervention/treatment||Phase|
|Alzheimer Disease||Drug: [F-18]AV-1451-PET||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||160 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy|
|Estimated Study Start Date :||June 1, 2020|
|Estimated Primary Completion Date :||June 1, 2022|
|Estimated Study Completion Date :||June 1, 2024|
All participants in this study will undergo a tau-PET imaging using the tracer [F-18]AV-1451 with a simultaneous PET/MRI system. The [F-18]AV-1451 dosage is 740MBq (10 mCi) given intravenously, and the PET/MRI imaging will occur 75-105 min after tracer injection.
All study participants will undergo brain imaging with [F-18]AV-1451-PET/MRI. [F-18]AV-1451 is a PET imaging agent used primarily to measure the amount of abnormal tau protein deposition the brain.
- Measurement of pathological tau deposition in the brain. [ Time Frame: 5 years ]The amount and regional distribution of pathological tau in the brains of study participants will be measured with [F-18]AV-1451-PET/MRI using standardized uptake value ratios (SUVRs) derived from the PET images.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03809351
|Contact: Jonathan McConathy, MD, PhDemail@example.com|
|Contact: April Riddle, RTfirstname.lastname@example.org|