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Comparison of Scalp Microbiome of the Psoriasis and Seborrheic Dermatitis Patients

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ClinicalTrials.gov Identifier: NCT03807453
Recruitment Status : Not yet recruiting
First Posted : January 17, 2019
Last Update Posted : January 17, 2019
Sponsor:
Collaborator:
Turkish Dermatology Association
Information provided by (Responsible Party):
Melek Aslan Kayıran, Istanbul Medeniyet University

Brief Summary:
A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiome of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiome differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

Condition or disease Intervention/treatment
Psoriasis Vulgaris Seborrheic Dermatitis Microbial Colonization Other: Microbiome

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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Comparison of Scalp Microbiome of the Patients With Psoriasis Vulgaris and Seborrheic Dermatitis
Estimated Study Start Date : January 30, 2019
Estimated Primary Completion Date : April 30, 2019
Estimated Study Completion Date : June 30, 2019

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Psoriasis Vulgaris patients-Lesion Other: Microbiome
The scalp microbiome

Psoriasis Vulgaris patients-Lesion free Other: Microbiome
The scalp microbiome

Seborrheic Dermatitis-Lesion Other: Microbiome
The scalp microbiome

Seborrheic Dermatitis-Lesion free Other: Microbiome
The scalp microbiome

Control Group Other: Microbiome
The scalp microbiome




Primary Outcome Measures :
  1. The scalp microbiome of the patients with psoriasis and seborrheic dermatitis [ Time Frame: 6 months ]

    The aim of this study is to compare the scalp microbiome of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment.

    The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.



Secondary Outcome Measures :
  1. The differences between the scalp microbiome of different countries [ Time Frame: 6 months ]
    Does the microbiota of the patients change between the countries? To our knowledge, there is no similar studies in present. Presenting the scalp microbiome of Turkish population can be a start to understand whether there is a difference in terms of the countries.



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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic and community sample
Criteria

Inclusion Criteria:

  1. Patients with scalp psoriasis
  2. Patients with seborrheic dermatitis
  3. Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months

Exclusion Criteria:

  1. Patients who do not want to participate in the study
  2. Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
  3. Those with chronic diseases that may affect skin microbiome
  4. Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
  5. Patients who are using topical or systemic drugs for their illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03807453


Contacts
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Contact: Melek Aslan Kayıran, M.D. +905325232873 melekaslan@gmail.com

Locations
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Turkey
Melek Aslan Kayıran
Istanbul, Turkey
Sponsors and Collaborators
Istanbul Medeniyet University
Turkish Dermatology Association

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Responsible Party: Melek Aslan Kayıran, Dermatologist, M.D., Istanbul Medeniyet University
ClinicalTrials.gov Identifier: NCT03807453     History of Changes
Other Study ID Numbers: IstanbulMU2
First Posted: January 17, 2019    Key Record Dates
Last Update Posted: January 17, 2019
Last Verified: January 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Melek Aslan Kayıran, Istanbul Medeniyet University:
Psoriasis Vulgaris
Seborrheic Dermatitis
Scalp
Microbiome

Additional relevant MeSH terms:
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Psoriasis
Dermatitis
Dermatitis, Seborrheic
Communicable Diseases
Infection
Skin Diseases, Papulosquamous
Skin Diseases
Sebaceous Gland Diseases
Skin Diseases, Eczematous