MRI Maker of Perioperative Neurocognitive Disorder (MRIPND)
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Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
Condition or disease
Necrosis of Femoral HeadKnee OsteoarthritisFracture of Lower Limb
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Layout table for eligibility information
Ages Eligible for Study:
60 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients elder than 60 years old elective to undergo lower limb surgery and conform to the including criteria would be recruited.
Age ≥ 60 years
Spoke proficient Chinese
Selected to lower limb osteopathic surgery
Informed consent signed by the patient
Underwent general anesthesia
Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
Several audition or vision disorder
With standard contraindications to MRI examinations
Unwillingness to comply with the protocol or procedures.