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Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma

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ClinicalTrials.gov Identifier: NCT03752710
Recruitment Status : Completed
First Posted : November 26, 2018
Last Update Posted : November 27, 2018
Sponsor:
Information provided by (Responsible Party):
Lv Yingjuan, Tianjin Medical University Eye Hospital

Brief Summary:
In this work, we evaluated the biometry data of lens subluxation inducing acute angle closure which were misdiagnosed as primary angle closure at the first visit, and compared with the data of chronic angle closure glaucoma, cataract, primary acute angle closure.

Condition or disease
Subluxation of Lens

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Study Type : Observational
Actual Enrollment : 183 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Biometric Indicators of Eyes With Occult Lens Subluxation
Actual Study Start Date : January 2016
Actual Primary Completion Date : December 2017
Actual Study Completion Date : December 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma

Group/Cohort
Acute primary angle closure
Acute secondary angle closure induced by LS
Cataract
Primary chronic angle closed glaucoma



Primary Outcome Measures :
  1. Eye anterior segment biometry [ Time Frame: 1 day ]
    Anterior segment biometry measure by Lenstar LS900

  2. Intraocular pressure [ Time Frame: 1 year ]
    Intraocular pressure was measured by Goldmann tonometer

  3. visual acuity [ Time Frame: 1 year ]
    visual acuity before and after surgery



Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
This retrospective case study included 17 eyes of 17 patients with ASAC-LS, who were misdiagnosed with APACG on their first visit. In addition, 56 eyes of 56 patients diagnosed with APACG, 54 eyes of 54 patients diagnosed with CPACG, and 56 eyes of 56 patients diagnosed with cataract were also included. All of the patients were admitted from Jan 10, 2016 to Dec 28, 2017 in Tianjin Medical University Hospital. This study was conducted in accordance with the Helsinki Declaration and was approved by the Ethics Committee of Tianjin Medical University Eye Hospital.
Criteria

ASAC-LS was diagnosed according to the following criteria, including sudden pain in the eye, decreased vision with or without nausea and vomiting. Slit lamp microscopy reveals phacodonesis, lens inclination or vitreous herniation into the anterior chamber, central and peripheral shallow anterior chamber, and asymmetric iris bulge. All patients were confirmed during the surgery to have LS.

APACG was diagnosed with the following criteria6, 7 8, including substantially elevated IOP and closed angle, acute eye pain, blurred vision, or nausea and vomiting. More importantly, ischemic injury caused by acute ocular hypertension, ciliary or mixed congestion, corneal edema, and glaucoma flecks should be detected.

The diagnostic criteria of CPACG included narrow angle with anterior synechiae of varying widths, IOP > 22 mmHg, and glaucomatous optic disc damage and visual field shrinkage9-11 The angle closure should be more than two quadrants, yet there was no ischemic injury in the anterior segment caused by acute ocular hypertension.

Exclusion criteria were history of laser peripheral iridotomy or peripheral iridectomy, glaucoma filtration surgery, angle closure caused by ocular trauma, uveitis, neovascularization or lens swelling or hyper mature lens. The patients with acute angle closure in both eyes were excluded. The subjects in which Lenstar LS900 examination could not be performed because of severe lens opacity or corneal edema were also not included in the study.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Lv Yingjuan, Dr Lv Yingjuan, Tianjin Medical University Eye Hospital
ClinicalTrials.gov Identifier: NCT03752710    
Other Study ID Numbers: Tianjin LS study
First Posted: November 26, 2018    Key Record Dates
Last Update Posted: November 27, 2018
Last Verified: November 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Joint Dislocations
Lens Subluxation
Joint Diseases
Musculoskeletal Diseases
Wounds and Injuries
Lens Diseases
Eye Diseases