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The Eosinophils Percentage Predicts In-hospital Major Adverse Cardiac Events in STEMI Patients After PCI

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ClinicalTrials.gov Identifier: NCT03740776
Recruitment Status : Completed
First Posted : November 14, 2018
Last Update Posted : November 14, 2018
Sponsor:
Information provided by (Responsible Party):
Dongying Zhang, Chongqing Medical University

Brief Summary:
Eosinophils (EOS) in peripheral blood are significantly decreased in ST-segment elevation myocardial infarction (STEMI) and the reduced EOS indicates severe myocardial damage. Whether EOS is a good predictor for in-hospital major adverse cardiac events (MACEs) of patients with ST-segment elevation myocardial infarction remains unknown. The aims of this study was to evaluate prognostic role of EOS for in-hospital MACEs in STEMI patients who have undergone primary percutaneous coronary intervention (PCI)

Condition or disease
ST Elevation Myocardial Infarction

Detailed Description:
The investigators retrospectively analyzed the clinical data of 518 patients with STEMI after PCI. MACEs were defined as cardiac arrest, cardiac rapture, malignant arrhythmia and cardiac death. The receiver operating characteristic (ROC) curves were used to demonstrate the prognostic value of EOS% in in-hospital MACEs. All patients were divided into 2 groups according to the best cut-off EOS% value, including reduced EOS% group and control group. Cox regression analyses and KM survival curve were used to calculate the correlated between EOS with in-hospital MACEs.

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Study Type : Observational
Actual Enrollment : 2 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Eosinophils Percentage Predicts In-hospital Major Adverse Cardiac Events in Patients With ST-elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention
Actual Study Start Date : October 1, 2015
Actual Primary Completion Date : August 1, 2017
Actual Study Completion Date : November 1, 2018

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. major adverse cardiac events [ Time Frame: The median time of 7 days ]
    the relationship between reduced eosinophils percentage and in-hospital MACE



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
STEMI Patients
Criteria

Inclusion Criteria:

  1. Patients with STEMI who underwent PCI within 12 hours from symptom onset
  2. Patients from whom informed consent has been properly obtained in writing prior to start of the trial.

Exclusion Criteria:

  1. Patients with previous myocardial infarction, congenital heart disease
  2. Patients with liver disease, and renal failure
  3. Patients with immunologic disease, malignant tumors, pregnancy, infection caused by various pathogens, chronic inflammatory disease, trauma.

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Responsible Party: Dongying Zhang, Professor, Chongqing Medical University
ClinicalTrials.gov Identifier: NCT03740776     History of Changes
Other Study ID Numbers: 2018-35
First Posted: November 14, 2018    Key Record Dates
Last Update Posted: November 14, 2018
Last Verified: November 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Myocardial Infarction
ST Elevation Myocardial Infarction
Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases