Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients
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The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The project population will include adult (> 18 years) patients with a history of grass and birch pollen allergy verified by positive skin prick test and allergen-specific IgE in blood. The study population may also include patients with ongoing or completed AIT.
History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens
Male or female patients older than 18 years
Written informed consent for providing blood and also to allow experimental manipulation
Age < 18 years
Any corticosteroids within the last three days
Oral corticosteroid therapy within the last ten days
Parenteral depot corticosteroids within the last three months