The Relationship Between Postoperative Changes of Oral and Intestinal Flora and Prognosis
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|ClinicalTrials.gov Identifier: NCT03667495|
Recruitment Status : Recruiting
First Posted : September 12, 2018
Last Update Posted : September 21, 2018
|Condition or disease|
|Gut Microbiota Oral Microbiota Colorectal Cancer|
Colorectal cancer is a major cause of cancerrelated deaths and the third most commonly diagnosed cancer worldwide.Current estimates indicate that 20-30% of those who undergo treatment will experience recurrence and 35% of all patients will die within 5 years.
The human colon plays host to a diverse and metabolically complex community of microorganisms. While the specific oral microbiome has been found to contribute to the development of colorectal cancer. Investigators speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment.
Patients are routinely offered surveillance in order to detect disease recurrence at an early, asymptomatic stage, with the intention of improving survival. Nevertheless, controversy continues to surround the optimal surveillance protocols. Investigators aim to discover if any difference of oral microbiota is exist in patients who suffer from relapse compared with patients who do not.
Future surveillance after colorectal cancer treatment should focus on risk-stratification. Finally investigators will develop patient-centred programmes of surveillance protocols base on microbiota analysis.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Postoperative Oral and Intestinal Flora Changes in Patients With Colorectal Cancer and the Relationship Between These Changes and Prognosis|
|Actual Study Start Date :||November 1, 2017|
|Estimated Primary Completion Date :||November 1, 2019|
|Estimated Study Completion Date :||March 1, 2021|
Patients who suffered colorectal cancer or adenoma relapse after curative surgery
Patients who get remission after curative surgery
- Colorectal cancer or adenoma recurred [ Time Frame: 12 months after surgery ]Use colonoscopy to check for recurrence of colorectal cancer
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03667495
|Contact: Yunwei Weifirstname.lastname@example.org|
|Contact: Rui Gengemail@example.com|
|Harbin, Heilongjiang, China, 150001|
|Contact: Yunwei Wei firstname.lastname@example.org|
|Study Director:||Yunwei Wei||First Affiliated Hospital of Harbin Medical University|