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Atrial Function and Supraventricular Arrhythmia of the Veteran Athlete. (FA2V)

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ClinicalTrials.gov Identifier: NCT03665324
Recruitment Status : Completed
First Posted : September 11, 2018
Last Update Posted : September 11, 2018
Sponsor:
Information provided by (Responsible Party):
Rennes University Hospital

Brief Summary:

Supraventricular arrhythmias (including atrial fibrillation) are the most common arrhythmias of the veteran athlete and have a major impact in terms of morbidity and mortality. Although moderate sports practice has been shown to decrease the occurrence of these arrhythmias, it has also been shown that very intense athletic activity is associated with an increased risk of developing atrial fibrillation. The pathophysiological mechanism is not clearly understood. However, it has already been shown that intensive sports practice leads to electrical and morphological atrial remodeling, which could be the cause of the occurrence of supraventricular arrhythmias for these athletes.

For sedentary patients, two major tools predict the risk of the onset of supraventricular arrhythmia: the electrocardiogram (ECG) and transthoracic echocardiography (ETT), particularly with the study of atrial function by the analysis of myocardial deformities.


Condition or disease Intervention/treatment
Supraventricular Arrhythmias Other: Evaluation of the relationship between atrial remodeling evaluated by ECG and ETT with the occurrence of supraventricular arrhythmias

Detailed Description:

No studies have tested these two tools for the evaluation of atrial remodeling of the veteran athlete to predict which ones are at risk of developing supraventricular arrhythmias.

However, the identification of predictive factors would make it possible to identify at-risk athletes and thus provide them with adapted sporting practice advice and personalized follow-up.

The aim of the study is to evaluate the relationship between atrial remodeling assessed by ECG and ETT with the occurrence of supraventricular arrhythmia by comparing an athlete group with supraventricular arrhythmia with a control group of healthy athletes.


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Study Type : Observational
Actual Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Atrial Function and Supraventricular Arrhythmia of the Veteran Athlete.
Actual Study Start Date : April 28, 2017
Actual Primary Completion Date : May 15, 2017
Actual Study Completion Date : May 15, 2017

Group/Cohort Intervention/treatment
Veteran athletes with Supraventricular arrhythmias
Subjects who consulted in the Sports Medicine Department between January 1, 2010 and January 1, 2017 Veteran athletes (age> 35 years) with documented paroxysmal supraventricular arrhythmias.
Other: Evaluation of the relationship between atrial remodeling evaluated by ECG and ETT with the occurrence of supraventricular arrhythmias

Subjects will be retrospectively retrieved from the Sport Medicine Service of Rennes University Hospital database.

Medical data will then be collected from the athletes' medical records. The ECG present in the medical file will be reinterpreted to obtain the resting heart rate, the amplitude of the P wave, the morphology of the P wave and the duration of the PR space.

The data from the stress test will be found from reports in the medical records: resting heart rate, maximum heart rate, sustained peak load, arrhythmia during the test.

ETTs will be retrieved from the local server. They will be reinterpreted to collect anatomical and functional cardiac data necessary for the study.


Veteran athletes without supraventricular arrhythmia
Subjects who consulted in the Sports Medicine Department between January 1, 2010 and January 1, 2017 Veteran athletes (age> 35 years) without documented supraventricular arrhythmia.
Other: Evaluation of the relationship between atrial remodeling evaluated by ECG and ETT with the occurrence of supraventricular arrhythmias

Subjects will be retrospectively retrieved from the Sport Medicine Service of Rennes University Hospital database.

Medical data will then be collected from the athletes' medical records. The ECG present in the medical file will be reinterpreted to obtain the resting heart rate, the amplitude of the P wave, the morphology of the P wave and the duration of the PR space.

The data from the stress test will be found from reports in the medical records: resting heart rate, maximum heart rate, sustained peak load, arrhythmia during the test.

ETTs will be retrieved from the local server. They will be reinterpreted to collect anatomical and functional cardiac data necessary for the study.





Primary Outcome Measures :
  1. Study of atrial function by analysis of myocardial strain. [ Time Frame: At the inclusion day ]
    Myocardial strain in extracted from ETT and compared between the two groups.



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Ages Eligible for Study:   35 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
Veteran athletes who consulted in the Sports Medicine Department between January 1, 2010 and January 1, 2017
Criteria

Inclusion Criteria:

  • Supraventricular arrhythmia group : Veteran athletes with documented paroxysmal supraventricular arrhythmias.
  • Control Group : Veteran athletes without documented supraventricular arrhythmia.

Exclusion Criteria:

  • Any cardiopathy (valvulopathy, coronary heart disease, etc.).
  • Minor patients,
  • Major patients subject to legal protection (legal safeguards, guardianship)
  • Persons deprived of their liberty
  • Patients opposed to the use of their personal data.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03665324


Locations
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France
Rennes University Hospital
Rennes, France, 35000
Sponsors and Collaborators
Rennes University Hospital
Investigators
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Principal Investigator: frederic SCHNELL, MD Rennes University Hospital

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Responsible Party: Rennes University Hospital
ClinicalTrials.gov Identifier: NCT03665324     History of Changes
Other Study ID Numbers: 35RC17_3066
First Posted: September 11, 2018    Key Record Dates
Last Update Posted: September 11, 2018
Last Verified: September 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Rennes University Hospital:
Supraventricular arrhythmias
veteran athlete
ECG
ETT