The Effect of Hawthorn on Lipoprotein Cholesterol Ratio in Schizophrenics With Antipsychotics
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|ClinicalTrials.gov Identifier: NCT03663465|
Recruitment Status : Completed
First Posted : September 10, 2018
Last Update Posted : September 10, 2018
Importance: The problems of side effects of metabolic disturbances in schizophrenic patients have been of worldwide concern for some time. Patients with dyslipidemia have an increased risk of cardiovascular diseases. A Chinese herb, Hawthorn, is widely used for the treatment of dyslipidemia.
Objective: Therefore, this study aimed to investigate the effect of Hawthorn on lipid profile levels in schizophrenic patients treated with antipsychotics.
Design, Setting, and Participants: A longitudinal case-control study was used in a general hospital in Taiwan. A total of 59 schizophrenics treated with antipsychotics, and 76 healthy adult subjects, who were all hospital workers, were enrolled in this study.
Main outcomes and measures: All participants received Hawthorn at a dose of 3 gm/day for six months.
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia||Other: Hawthorn Drug: SGAs||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||135 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||case control study|
|Masking:||Double (Participant, Investigator)|
|Masking Description:||two groups of participants and investigator|
|Official Title:||The Disparity of Hawthorn Effects to Triglyceride/High-density Lipoprotein Cholesterol Ratio in Schizophrenics With Antipsychotics|
|Actual Study Start Date :||January 1, 2013|
|Actual Primary Completion Date :||December 31, 2013|
|Actual Study Completion Date :||July 31, 2014|
Experimental: Hawthorn and SGAs
SGAs has a dose of 3-20 gm/day, Hawthorn at a dose of 3 gm/day for six months.
Other Name: second-generation antipsychotics
Active Comparator: Hawthorn
Hawthorn at a dose of 3 gm/day for six months.
- lipid profiles [ Time Frame: three days ]lipid profiles (including TC, TG, HDL, LDL) were collected three times (at first week, 12th week and 24th week. Total collecting day were three days.