Hyperglycemia, Exercise, and Endothelial Function
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|ClinicalTrials.gov Identifier: NCT03651713|
Recruitment Status : Recruiting
First Posted : August 29, 2018
Last Update Posted : September 25, 2019
|Condition or disease||Intervention/treatment||Phase|
|Endothelial Function Hyperglycemia||Behavioral: GLU+EX Dietary Supplement: GLU||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||Randomized|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of Short-Term Glucose Loading on Vascular Function|
|Actual Study Start Date :||October 15, 2018|
|Estimated Primary Completion Date :||December 1, 2019|
|Estimated Study Completion Date :||December 1, 2019|
Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.
Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.
Active Comparator: GLU
Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.
Dietary Supplement: GLU
Subjects will consume a 75g glucose beverage three times daily over a seven-day period.
- Change in Vascular Endothelial Function [ Time Frame: Before and after the seven-day intervention in both groups. ]Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.
- Central Blood Pressure [ Time Frame: Before and after the seven-day intervention in both groups. ]Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions.
- Physical Activity [ Time Frame: Continuously throughout the seven-day intervention. ]Steps per day will be recorded via accelerometry throughout the intervention in both groups.
- Caloric Consumption [ Time Frame: Continuously throughout the seven-day intervention. ]Subjects will record their dietary intake throughout the intervention.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03651713
|Contact: Darren P Casey, PhDemail@example.com|
|United States, Iowa|
|Medical Education Building||Recruiting|
|Iowa City, Iowa, United States, 52242|
|Contact: Darren P Casey, Ph.D. 319-334-1009 firstname.lastname@example.org|