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Patients and partners undergoing an autologous IVF cycle will be recruited to participate in this prospective observational study investigating the microbiome and its association with IVF pregnancy outcomes. During the the controlled ovarian hyperstimulation cycle as well as the frozen embryo transfer cycle, a number of specimens will be collected for next generation sequencing of 16S rRNA to evaluate the microbiome profile of the reproductive and gastrointestinal tracts. Data on pregnancy outcomes will be collected prospectively and evaluated to identify associations with the microbiome.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients and partners undergoing IVF
Patients initiating an autologous IVF cycle
Patient age 18-45; partner age 18-60
Partner planning to provide fresh semen sample on day of oocyte retrieval
Patients planning to undergo preimplantation genetic screening (PGS) of embryos with single embryo transfer (SET)
> 1 prior failed IVF cycle
Third party reproduction
Planning to bank embryos
Partner using cryo sperm or surgical sperm on day of retrieval
Male or female partner antibiotic use within 1 month of IVF cycle start
Mullerian anomalies, excluding arcuate uterus
History of uterine surgery, excluding polypectomy, D&C, and Cesarean section
Communicating hydrosalpinx without plans for surgical correction prior to embryo transfer