Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study (INCA)
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|ClinicalTrials.gov Identifier: NCT03617302|
Recruitment Status : Recruiting
First Posted : August 6, 2018
Last Update Posted : January 29, 2019
|Condition or disease||Intervention/treatment||Phase|
|Aging Arterial Stiffness Endothelial Dysfunction Hypertension Cognitive Decline||Drug: Experimental: Nitrate-containing Drug: Placebo: Nitrate-depleted||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effects of Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study|
|Actual Study Start Date :||November 1, 2018|
|Estimated Primary Completion Date :||October 2019|
|Estimated Study Completion Date :||February 2020|
Experimental: Beetroot juice
10-grams of nitrate-containing beetroot concentrate diluted in 120-180 milliliters of water.
Drug: Experimental: Nitrate-containing
Placebo Comparator: Placebo Beetroot juice
10 grams of nitrate-depleted beetroot concentrate balanced for anti-oxidant content diluted in 120-180 milliliters of water.
Drug: Placebo: Nitrate-depleted
- Acute change in carotid artery stiffness [ Time Frame: 2-hours ]Common carotid artery stiffness measured by ultrasonography and applanation tonometry.
- Acute change in cerebral blood flow [ Time Frame: 2-hours ]Large cerebral artery blood flow will be measured using 4-Dimensional (4D) phase contrast vastly undersampled isotropic projection imaging (pcVIPR) magnetic resonance imaging (MRI).
- Internal carotid artery endothelium-dependent dilation [ Time Frame: 2-hours ]Endothelium-dependent dilation of the internal carotid artery in response to hypercapnia will be measured using ultrasonography.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03617302
|Contact: Gary Pierce, PhD||(319)firstname.lastname@example.org|
|Contact: Lyndsey DuBose, MS||(319)email@example.com|
|United States, Iowa|
|University of Iowa||Recruiting|
|Iowa City, Iowa, United States, 52242|
|Contact: Gary Pierce, PhD firstname.lastname@example.org|
|Contact: Lyndsey DuBose, MS email@example.com|
|Principal Investigator:||Gary Pierce, PhD||University of Iowa|