Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study (INCA)
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|ClinicalTrials.gov Identifier: NCT03617302|
Recruitment Status : Recruiting
First Posted : August 6, 2018
Last Update Posted : January 29, 2019
|Condition or disease||Intervention/treatment||Phase|
|Aging Arterial Stiffness Endothelial Dysfunction Hypertension Cognitive Decline||Drug: Experimental: Nitrate-containing Drug: Placebo: Nitrate-depleted||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effects of Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study|
|Actual Study Start Date :||November 1, 2018|
|Estimated Primary Completion Date :||October 2019|
|Estimated Study Completion Date :||February 2020|
Experimental: Beetroot juice
10-grams of nitrate-containing beetroot concentrate diluted in 120-180 milliliters of water.
Drug: Experimental: Nitrate-containing
Placebo Comparator: Placebo Beetroot juice
10 grams of nitrate-depleted beetroot concentrate balanced for anti-oxidant content diluted in 120-180 milliliters of water.
Drug: Placebo: Nitrate-depleted
- Acute change in carotid artery stiffness [ Time Frame: 2-hours ]Common carotid artery stiffness measured by ultrasonography and applanation tonometry.
- Acute change in cerebral blood flow [ Time Frame: 2-hours ]Large cerebral artery blood flow will be measured using 4-Dimensional (4D) phase contrast vastly undersampled isotropic projection imaging (pcVIPR) magnetic resonance imaging (MRI).
- Internal carotid artery endothelium-dependent dilation [ Time Frame: 2-hours ]Endothelium-dependent dilation of the internal carotid artery in response to hypercapnia will be measured using ultrasonography.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03617302
|Contact: Gary Pierce, PhD||(319)email@example.com|
|Contact: Lyndsey DuBose, MS||(319)firstname.lastname@example.org|
|United States, Iowa|
|University of Iowa||Recruiting|
|Iowa City, Iowa, United States, 52242|
|Contact: Gary Pierce, PhD email@example.com|
|Contact: Lyndsey DuBose, MS firstname.lastname@example.org|
|Principal Investigator:||Gary Pierce, PhD||University of Iowa|