Thyroid Dysfunction in Female Patients With Acne Vulgaris: [ Relation to Other Variables ]
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|ClinicalTrials.gov Identifier: NCT03602534|
Recruitment Status : Not yet recruiting
First Posted : July 27, 2018
Last Update Posted : July 31, 2018
Acne is a chronic inflammatory disease of the pilo-sebaceous unit with a multi-factorial etiology. It is one of the most frequent cutaneous diseases, affecting more than eighty percent of the population at some point in their lives .
Endocrine factors especially androgens and steroids are one of multiple factors provoked to be involved in pathogenesis of acne . Thyroid hormones have steroid like action that have many regulatory functions in many body organ functions including skin and pilosebaceous unit. Furthermore, subtle thyroid dysfunction was shown to have a role in many disease conditions.
Thyroid hormone action on sebaceous glands is unclear. In hypothyroid states, sebocytes exhibit reduced rates of secretion that increases with thyroxine administration .
|Condition or disease|
|Acne Vulgaris Thyroid Dysfunction|
Most of studies about thyroid dysfunction in acne patients focused on adult acne population especially females and searched for presence or absence of associating anti-thyroid antibodies with controversial results .
Some other studies were concerned with the impact of acne treatments as tetracycline, isotretinoin or radiotherapy on thyroid pathologies and dysfunction .
Global Acne Severity Scale (GAGS) is a simple, accurate, fast method for the determination of severity of acne, and it requires no special equipment and is relatively cost-effective. Its personal and interpersonal differences is low and it was first used by Doshi and his colleagues in 1997 in USA .
To the best of knowledge, little is published about thyroid dysfunction in acne female patients of different age categories and correlating thyroid function with other important patient and acne variables as body mass index (BMI) , age (starting from 16 years) , acne type, severity and duration.
|Study Type :||Observational|
|Estimated Enrollment :||79 participants|
|Official Title:||Thyroid Dysfunction in Female Patients With Acne Vulgaris: [ Relation to Other Variables ]|
|Estimated Study Start Date :||December 2018|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2019|
cases with variable acne severity scores
- thyroid hormone level in female acne vulgaris patients [ Time Frame: 1 hour ]Peripheral blood samples will be taken , for measurement of thyroid hormone by ELISA
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03602534
|Contact: Emad Tahafirstname.lastname@example.org|
|Contact: Reham Abdel-Gaberemail@example.com|
|DGamal||Not yet recruiting|
|Contact: Reham Abdel-Gaber 01005043777 firstname.lastname@example.org|
|Study Director:||Emad Taha||Assiut University|