Cardiovascular Effects of High-Intensity Interval Training (HIIT)
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|ClinicalTrials.gov Identifier: NCT03602170|
Recruitment Status : Completed
First Posted : July 26, 2018
Last Update Posted : April 26, 2019
|Condition or disease||Intervention/treatment||Phase|
|Healthy Sedentary Adults With BP <140/90||Behavioral: High-Intensity Interval Training Behavioral: Moderate-Intensity Continuous Training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Cardiovascular Effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MCT)|
|Actual Study Start Date :||March 30, 2017|
|Actual Primary Completion Date :||November 6, 2018|
|Actual Study Completion Date :||November 6, 2018|
Experimental: High-Intensity Interval Training
8 weeks of high-intensity interval training. Three sessions per week will be performed (24 total sessions).
Behavioral: High-Intensity Interval Training
Supervised exercise sessions will be performed on a upright cycle ergometer. Training sessions involve 20 minutes of exercise by completing 10 repetitions of 60 seconds of exercise at 90-95% maximal heart rate with 60 seconds of active rest between each repetition at 50-60% maximal heart rate.
Active Comparator: Moderate-Intensity Continuous Training
8 weeks of moderate-intensity continuous training. Three sessions per week will be performed (24 total sessions).
Behavioral: Moderate-Intensity Continuous Training
Supervised exercise sessions will be performed on a upright cycle ergometer. Training sessions involve 30 minutes of continuous exercise at 65-70% maximal heart rate.
- Blood Pressure [ Time Frame: Change from baseline resting blood pressure at 8 weeks ]Resting blood pressures measuring by automated oscillometric device
- Peak Aerobic Capacity [ Time Frame: Change from baseline VO2peak at 8 weeks ]Peak oxygen uptake (VO2peak/max) during incremental cycling exercise until exhaustion
- 24-Hour Ambulatory Blood Pressure [ Time Frame: Change from baseline 24-hour ambulatory blood pressure at 8 weeks ]24 hours of continuous ambulatory blood pressure monitoring by oscillometric device
- Pulse Wave Analysis [ Time Frame: Change from baseline central blood pressure measures at 8 weeks ]Central blood pressure measures assessed by radial tonometry
- Endothelial Function [ Time Frame: Change from baseline endothelial function at 8 weeks ]Assessed by brachial artery flow mediated dilation and change in blood in femoral artery in response to passive limb movement
- Arterial stiffness [ Time Frame: Change from baseline pulse wave velocity measures at 8 weeks ]Pulse wave velocity measures (carotid to femoral and femoral to distal) assessed by applanation tonometry
- Blood Pressure Reactivity [ Time Frame: Change from baseline blood pressure reactivity at 8 weeks ]Blood pressure response to graded exercise test and handgrip exercise
- Perceived Enjoyment of Exercise [ Time Frame: Measured after 4 and 8 weeks of training ]Enjoyment rating based on 18-item questionnaire
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03602170
|United States, Delaware|
|Department of Kinesiology and Applied Physiology, University of Delaware|
|Newark, Delaware, United States, 19713|
|Principal Investigator:||Bryce J Muth, MS||University of Delaware|
|Principal Investigator:||David G Edwards, PhD||University of Delaware|