Neural Indications of Stress-Induced Mental Overload
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|ClinicalTrials.gov Identifier: NCT03585205|
Recruitment Status : Recruiting
First Posted : July 12, 2018
Last Update Posted : July 12, 2018
|Condition or disease||Intervention/treatment||Phase|
|Healthy Stress, Psychological||Behavioral: Stress and cognitive load Induction||Not Applicable|
Research in the past years on stress and its influence on cognitive workload suggest that their relationship is not simply linear. On one hand, stress disrupts the processes of attention, memory and complicated decision making. While on the other hand, stress response allows the individual to recognize threats quickly, react accordingly, return the body to homeostasis, and prepare the organism to future challenges. However, it is still unclear why different individuals deal with cognitive workload under stress differently, and which brain mechanisms are underlying these processes.
In this current research the use of non invasive imaging techniques, such as EEG and fMRI, in addition to physiological measurements, such as heart rate, skin conductance, and eye movements, will allow an objective characterization of the individual's response to cognitive workload under stress.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Neural Indications of Stress-Induced Mental Overload|
|Actual Study Start Date :||October 23, 2017|
|Estimated Primary Completion Date :||September 1, 2018|
|Estimated Study Completion Date :||September 1, 2018|
Experimental: Stress and cognitive load Induction
Participants will engage in a computerized task which induces cognitive load. Each participant will perform the task once under a stress condition and once under a neutral (non-stress) condition.
Behavioral: Stress and cognitive load Induction
Participants will engage in demanding cognitive load computerized tasks (such as N-back and Stroop tasks). They will engage in these tasks once in a non-stressful (neutral condition), and once in a stressful condition.
Psychological stress will be induced by the following methods:
- Behavioral and fMRI (BOLD) [ Time Frame: 1 day ]We anticipate to see changes in relevant brain networks via fMRI (measuring BOLD signal), and performance in a computerized task.
- Changes in heart rate [ Time Frame: 1 day ]We expect stress to influence heart rate.
- Changes in electrodermal activity [ Time Frame: 1 day ]We expect both stress and cognitive load to influence the nor-adrenergic system. We expect to measure these effects via electrodermal activity.
- Changes in Pupil Dilation [ Time Frame: 1 day ]We expect both stress and load to influence the nor-adrenergic system. We expect to measure these effects via pupil dilation.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03585205
|Contact: Ayam Greental, BScemail@example.com|
|Principal Investigator:||Talma Hendler, MD, PhD||Tel-Aviv Sourasky Medical Center|