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Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

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ClinicalTrials.gov Identifier: NCT03564353
Recruitment Status : Recruiting
First Posted : June 20, 2018
Last Update Posted : June 20, 2018
Sponsor:
Information provided by (Responsible Party):
Sven Vanneste, The University of Texas at Dallas

Brief Summary:
The purpose of this study is to investigate whether we can improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task

Condition or disease Intervention/treatment Phase
Healthy Adults Device: tDCS Not Applicable

Detailed Description:

Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer's disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.

Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether it is possible to improve associative memory using tDCS, the performance in a Verbal Paired-Associate memory task of 4 groups targeting different areas will be compared.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Participants will be randomly assigned to one of four groups: (1) tDCS targeting location 1 paired with memory task (2) tDCS targeting location 2 with memory task (3) tDCS targeting location 3 paired with memory task (4) tDCS targeting location 4 paired with memory task
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation
Actual Study Start Date : June 7, 2018
Estimated Primary Completion Date : June 2019
Estimated Study Completion Date : June 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Arm Intervention/treatment
Experimental: memory task with tDCS location 1
memory task paired with tDCS targeting location 1
Device: tDCS
tDCS

Experimental: memory task with tDCS location 2
memory task paired with tDCS targeting location 2
Device: tDCS
tDCS

Experimental: memory task with tDCS location 3
memory task paired with tDCS targeting location 3
Device: tDCS
tDCS

Experimental: memory task with tDCS location 4
memory task paired with tDCS targeting location 4
Device: tDCS
tDCS




Primary Outcome Measures :
  1. Associative Memory assessed by a Verbal Paired-Associate test [ Time Frame: baseline and 1 week after the tDCS ]
    Changes in performance in the Verbal Paired-Associate memory task is compared between the 4 groups targeting different locations to investigate the influence of tDCS on Associative Memory.



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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age: 18-35 years
  • Native English Speaker

Exclusion Criteria:

  • History of severe head injuries, epileptic insults, or heart disease.
  • Severe psychiatric disorders and severe untreated medical problems.
  • acquainted with the foreign language used in the learning task
  • Contraindications for tDCS (pregnant women, implanted devices)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03564353


Locations
United States, Texas
The University of Texas of Dallas Recruiting
Richardson, Texas, United States, 75080
Contact: Sven Vanneste, Ph.D.    972-883-7275    ab_CLINT@utdallas.edu   
Contact    9728837275    Lab_CLINT@utdallas.edu   
Sponsors and Collaborators
The University of Texas at Dallas

Responsible Party: Sven Vanneste, Associate Professor, The University of Texas at Dallas
ClinicalTrials.gov Identifier: NCT03564353     History of Changes
Other Study ID Numbers: 17-34 CM
First Posted: June 20, 2018    Key Record Dates
Last Update Posted: June 20, 2018
Last Verified: June 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: Yes
Device Product Not Approved or Cleared by U.S. FDA: No

Keywords provided by Sven Vanneste, The University of Texas at Dallas:
transcranial Direct Current Stimulation (tDCS)
memory