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Impact of Renal Replacement Therapy on Coagulation Profile of Patients With Acute Renal Failure (HEMOSTIR)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03536195
Recruitment Status : Unknown
Verified May 2018 by University Hospital, Brest.
Recruitment status was:  Not yet recruiting
First Posted : May 24, 2018
Last Update Posted : May 24, 2018
Information provided by (Responsible Party):
University Hospital, Brest

Brief Summary:
Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

Condition or disease
Acute Renal Failure Hemorrhage Coagulation Disorder

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Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Impact of Renal Replacement Therapy on Coagulation Profile in Patients With Acute Renal Failure
Estimated Study Start Date : June 1, 2018
Estimated Primary Completion Date : June 1, 2019
Estimated Study Completion Date : June 1, 2019

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. visco elastometry [ Time Frame: H0 and H12-24 (within 24 hours after renal replacement therapy) ]
    ROTEM (Rotational Thromboelastometry)

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Critically ill patients with acute renal failure where the decision of renal replacement therapy has been made.

Inclusion Criteria:

  • critically ill patients
  • acute renal failure
  • renal replacement therapy
  • plasmatic urea > 20

Exclusion Criteria:

  • chronic renal failure
  • platelet count less than 80 Giga
  • V factor less than 70%

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03536195

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Contact: Cécile AUBRON 02 98 34 71 81

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CHRU de Brest
Brest, France, 29609
Contact: Cécile AUBRON   
Sponsors and Collaborators
University Hospital, Brest
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Responsible Party: University Hospital, Brest Identifier: NCT03536195    
Other Study ID Numbers: HEMOSTIR (29BRC17.0132)
First Posted: May 24, 2018    Key Record Dates
Last Update Posted: May 24, 2018
Last Verified: May 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University Hospital, Brest:
renal replacement therapy
acute renal failure
Additional relevant MeSH terms:
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Renal Insufficiency
Acute Kidney Injury
Hemostatic Disorders
Blood Coagulation Disorders
Pathologic Processes
Kidney Diseases
Urologic Diseases
Hematologic Diseases
Vascular Diseases
Cardiovascular Diseases
Hemorrhagic Disorders