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Gall Bladder Status Among Children With Chronic Haemolytic Anemia (GBSACWCHA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03533322
Recruitment Status : Unknown
Verified May 2018 by Shohnda Mohammed Nazeir, Assiut University.
Recruitment status was:  Not yet recruiting
First Posted : May 23, 2018
Last Update Posted : July 31, 2018
Sponsor:
Information provided by (Responsible Party):
Shohnda Mohammed Nazeir, Assiut University

Brief Summary:

Gall bladder status among children with chronic haemolytic anemia attending to Assuit University Children Hospital.

Hemolysis is defined as the premature destruction of red blood cells (RBCs) (a shortened RBC life span). Anemia results when the rate of destruction exceeds the capacity of the marrow to produce RBCs. Normal RBC survival time is 110-120 days (half-life: 55-60 days), and thus, approximately 0.85% of the most senescent RBCs are removed and replaced each day.

Patients with chronic haemolytic anemia are subjected to many complications of chronic haemolytic anemia e.g anemic heart failure, complications of blood transfusion as hepatitis and AIDS, hypersplenism, haemosiderosis ,among them there is incidence of gallbladder stone formation.

This work aims to a) to determine the prevalence of gall bladder diseases among patient with chronic haemolytic anemia.

b) to determine the risk factors of gall bladder diseases among patients with chronic haemolytic anemia.


Condition or disease
Gall Bladder Disease

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Gall Bladder Status Among Children With Chronic Haemolytic Anemia Attending to Assuit University Children Hospital
Estimated Study Start Date : October 1, 2018
Estimated Primary Completion Date : October 1, 2019
Estimated Study Completion Date : October 1, 2019

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. prevelance of gall bladder diseases in children with chronic hemolytic syndrome [ Time Frame: one year ]
    gall bladder diseases



Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All patients admitted to Assiut university children Hospital 1 year study

  • 2.4.4 -Study tools (in detail, e.g., lab methods, instruments, steps, chemicals, …): Full clinical history including (age of onset of chronic haemolytic anemia- type of chronic haemolytic anemia -frequency of blood transfusion - use of hydroxy urea - splenectomy or not- frequency of admission)
  • Detailed clinical examination
  • Abdominal ultrasound
  • Plain KUB (kidney ureter bladder) x-rayif radiopaque stone.
  • Compelete blood count
  • Liver function test
  • C- reactive protein
Criteria

Inclusion Criteria:

  • children between 1 :18 years known to have chronic haemolytic anemia.

Exclusion Criteria:

  • children below 1 year and above 18 years children had past history of cholecystectomy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03533322


Contacts
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Contact: shohnda nazeir, master 01064195028 shahdmohammed2060@gmail.com

Sponsors and Collaborators
Assiut University
Investigators
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Principal Investigator: abelatif abdelmoez, professor assiut universitypediatric hospital
Principal Investigator: shereen galal, assistprof assiut universitypediatric hospital
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Responsible Party: Shohnda Mohammed Nazeir, Gall bladder status among children with chronic haemolytic anemia attending to Assiut University children hospital, Assiut University
ClinicalTrials.gov Identifier: NCT03533322    
Other Study ID Numbers: gallbladderstatusinchhemlytic
First Posted: May 23, 2018    Key Record Dates
Last Update Posted: July 31, 2018
Last Verified: May 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Gallbladder Diseases
Urinary Bladder Diseases
Anemia, Hemolytic
Anemia
Hematologic Diseases
Urologic Diseases
Biliary Tract Diseases
Digestive System Diseases