Preoperative Methadone Single Dose Reduces Postoperative Morphine Consumption.
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|ClinicalTrials.gov Identifier: NCT03529032|
Recruitment Status : Completed
First Posted : May 18, 2018
Last Update Posted : July 3, 2018
|Condition or disease||Intervention/treatment||Phase|
|Pain, Postoperative||Drug: Methadone||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||160 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||A Preoperative Methadone Single Dose for Moderately to Severely Painful Surgery Reduces Postoperative Morphine Consumption Results From a Double-blind Pragmatic Clinical Trial|
|Study Start Date :||March 2012|
|Actual Primary Completion Date :||July 2013|
|Actual Study Completion Date :||May 2018|
No Intervention: Fentanyl group
Drug: Fentanyl Fentanyl group 3µg/kg to start surgery TIVA: general anesthesia will be based on Fentanyl an Propofol, titrated to achieve bispectral index (BIS) between 40-60.
Experimental: methadone group
Drug: methadone methadone group 0.2mg/kg to start surgery TIVA: general anesthesia will be based on Fentanyl an Propofol, titrated to achieve bispectral index (BIS) between 40-60.
methadone for control postoperative pain
- Difference of postoperative morphine consumption [ Time Frame: first 48 hours postoperatively ]Difference in milligrams of morphine used as rescue by patient controlled analgesia pump
- Difference in pain scores, using the Numeric Rating Scale [ Time Frame: first 72 hours postoperatively ]Difference in pain scores in rest and motion at 0,6,12,24,36,48,72 hours postoperative.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03529032
|Baden, Kanton Aargau, Switzerland, 5404|
|Principal Investigator:||Philipp Buehler, MD||Kantonsspital Baden|