Sleep Apnea in Acromegaly After Surgery
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03526016 |
Recruitment Status :
Recruiting
First Posted : May 16, 2018
Last Update Posted : August 20, 2021
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Sleep apnea is common in acromegaly and both diseases are independently associated with hypertension and insulin resistance contributing to increased morbidity and mortality. Respiratory polygraphy is a simpler alternative to in-laboratory polysomnography for the management of more symptomatic patients with obstructive sleep apnea.
The aim of this study is to evaluate the prevalence of sleep apnea by respiratory polygraphy, and to analyze the effect of transsphenoidal surgery on sleep apnea.
Condition or disease |
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Sleep Apnea |
Study Type : | Observational |
Estimated Enrollment : | 50 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Effect of Transsphenoidal Surgery on Sleep Apnea in Patients With Acromegaly |
Actual Study Start Date : | February 21, 2018 |
Estimated Primary Completion Date : | December 2021 |
Estimated Study Completion Date : | December 2021 |
- Change in Respiratory disturbance index [ Time Frame: Baseline and 3 months after transsphenoidal surgery ]Changes in respiratory events during sleep

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Ages Eligible for Study: | 18 Years to 99 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- patients with newly diagnosed acromegaly
Exclusion Criteria:
- patients who can not undergo transsphenoidal surgery

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03526016
Contact: Jinwoo Lee, MD | 82-2-2072-7593 | realrain7@gmail.com |
Korea, Republic of | |
Seoul National University Hospital | Recruiting |
Seoul, Korea, Republic of, 110744 | |
Contact: Jinwoo Lee, MD 82-2-2072-7593 realrain7@gmail.com |
Responsible Party: | Jinwoo Lee, Associate professor, Seoul National University Hospital |
ClinicalTrials.gov Identifier: | NCT03526016 |
Other Study ID Numbers: |
1802032919 |
First Posted: | May 16, 2018 Key Record Dates |
Last Update Posted: | August 20, 2021 |
Last Verified: | August 2021 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Sleep Apnea Acromegaly Transsphenoidal surgery Respiratory polygraphy |
Acromegaly Apnea Sleep Apnea Syndromes Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases |
Bone Diseases, Endocrine Bone Diseases Musculoskeletal Diseases Hyperpituitarism Pituitary Diseases Hypothalamic Diseases Brain Diseases Central Nervous System Diseases Endocrine System Diseases |