Maintenance Treatment With BGB-290 Versus Placebo in Patients With Platinum-sensitive Recurrent Ovarian Cancer
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To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese patients with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR) after platinum-based chemotherapy
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Histologically diagnosed high-grade serous or endometrioid ovarian cancer (including primary peritoneal and fallopian tube cancer)
Completion of ≥2 previous platinum-containing regimens (eg, carboplatin or cisplatin)
Complete response (CR) or partial response (PR) achieved with last platinum-based chemotherapy regimen as determined by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1
Ability to be randomized ≤8 weeks after last dose of platinum
Prior treatment with a poly (ADP-ribose) polymerase (PARP) inhibitor
Progressive disease (PD) as per CA-125 criteria before randomization
Diagnosis of myelodysplastic syndrome (MDS)
Known history of intolerance to the excipients of the Pamiparib capsule