Risk Factors of Meconium Obstruction and Respiratory Distress Syndrome in Preterm Infants
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|ClinicalTrials.gov Identifier: NCT03513640|
Recruitment Status : Recruiting
First Posted : May 1, 2018
Last Update Posted : March 31, 2020
Although the pathophysiology of meconium obstruction of prematurity (MOP) is not clear, it is known that the decrease of the intestinal peristalsis due to decreased intestinal perfusion during antenatal or perinatal period. Recently, the level of citrulline has been used as an index of function and injury of the small intestine State. This study aimed to evaluate citrulline level of cord blood as a marker for early detection and observe changes in intestinal blood flow in MOP patient.
And We aimed to confirm the efficacy of the AT/ET ratio (ratio of the pulmonary artery time-to-peak velocity interval to the right ventricular ejection time) of the prenatal pulmonary artery as a noninvasive predictor of neonatal respiratory distress syndrome.
|Condition or disease|
|Meconium Obstruction of Prematurity Respiratory Distress Syndrome in Premature Infant|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Prospective Cohort for Finding Risk Factors of Meconium Obstruction and Respiratory Distress Syndrome in Preterm Infants|
|Actual Study Start Date :||April 13, 2018|
|Estimated Primary Completion Date :||April 2021|
|Estimated Study Completion Date :||April 2021|
- Comparison of citrulline level between the meconium obstruction group and the normal feeding advance group [ Time Frame: within 6 hours after birth ]check the citrulline llevel from blood at birth
- Comparison of prenatal AT/ET ratio of fetal pulmonary artery between respiratory distress syndrome group and the normal respiration group [ Time Frame: within 10 days before delivery ]Check the AT/ET ratio of fetal pulmonary artery within 10 days before birth
Biospecimen Retention: Samples Without DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03513640
|Contact: Seung Han Shin, M.D.||+firstname.lastname@example.org|
|Contact: Ee-Kyung Kim, PhD.||+email@example.com|