Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
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|ClinicalTrials.gov Identifier: NCT03507218|
Recruitment Status : Recruiting
First Posted : April 25, 2018
Last Update Posted : November 2, 2018
PANS is an illness that comes on suddenly in children. The full name is Pediatric Acute-Onset Neuropsychiatric Syndrome. It can cause sudden obsessive-compulsive behaviors. It can also cause children to suddenly restricte their food intake. Researchers want to learn more about children with PANS. They also want to learn more about the illness.
To study some disorders of behavior and emotion that start in childhood.
Children 3 14 years old who have had severe obsessive-compulsive symptoms or food restriction start quickly
Parents will answer questions. The topics include:
Their child s medical history
Their child s physical and mental health
Their family history. The focus will be on neurodevelopmental and psychiatric conditions. A family tree will be drawn.
Participants will have a physical exam.
Participants may take tests on paper or computer. These will focus on thinking, memory, and behavior.
Participants and parents will give a blood sample.
Participants will have magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal scanner.
Participants may have photos or videos taken.
Participants may have other tests. These may include heart tests, sleep tests, and lumbar puncture.
Sponsoring Institute: National Institute of Mental Health
|Condition or disease|
|Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||6400 participants|
|Official Title:||Clinical, Laboratory, and Biomedical Characterization of Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)|
|Actual Study Start Date :||March 20, 2018|
|Estimated Primary Completion Date :||December 31, 2020|
|Estimated Study Completion Date :||May 31, 2030|
Children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
- Establish national database and samples repository for pediatric acute-onset neuropsychiatric syndrome (PANS) [ Time Frame: Study Completion ]
- Identify unique and distinctive features of subgroups of patients with PANS, in order to determine the shared disease mechanism [ Time Frame: Study completion ]
- Elucidate the role of immune dysfunction in the syndrome of PANS, as well as for subgroups of patients [ Time Frame: Study completion ]
- Determine role of environmental pathogens, such as Group A streptococci, in the etiopathogenesis of PANS [ Time Frame: Study completion ]
- Investigate factors influencing host susceptibility and resistance [ Time Frame: Study completion ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03507218
|Contact: Margaret J Pekar||(301) firstname.lastname@example.org|
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|University of Arizona||Recruiting|
|Tucson, Arizona, United States, 85724|
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|Lucille Salter Packer Children's Hospital||Recruiting|
|Stanford, California, United States, 94304|
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|Wilmington, Delaware, United States, 19803|
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|Tampa, Florida, United States, 33620|
|United States, Maryland|
|National Institutes of Health Clinical Center||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
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|Harvard Medical School||Recruiting|
|Boston, Massachusetts, United States, 02115|
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|University of Minnesota||Recruiting|
|Minneapolis, Minnesota, United States, 55415|
|United States, Missouri|
|University of Missouri||Recruiting|
|Columbia, Missouri, United States, 65205|
|Principal Investigator:||Susan E Swedo, M.D.||National Institute of Mental Health (NIMH)|