Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal Insufficiency
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|ClinicalTrials.gov Identifier: NCT03505775|
Recruitment Status : Completed
First Posted : April 23, 2018
Last Update Posted : April 23, 2018
|Condition or disease||Intervention/treatment||Phase|
|Adrenal Insufficiency||Diagnostic Test: 23Na magnetic resonance imaging||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na Magnetic Resonance Imaging in Patients With Chronic Adrenal Insufficiency Compared to Healthy Subjects|
|Actual Study Start Date :||February 14, 2017|
|Actual Primary Completion Date :||October 31, 2017|
|Actual Study Completion Date :||October 31, 2017|
A 23Na magnetic resonance imaging of the calf (muscle and skin) was performed in every participating patient after clinical and laboratory examinations.
Diagnostic Test: 23Na magnetic resonance imaging
Imaging/diagnostic: Evaluation of the muscular and cutaneous sodium storage by 23Na magnetic resonance imaging. 23Na magnetic resonance imaging: 23NA-MRI protocol on a 3T scanner (Magnetom PRISMA, Siemens, Erlangen) implementing a 3D sequence.
- Muscle sodium content [ Time Frame: 6 months ]Assessment of the sodium content of the calf muscle. Relative sodium signal intensities were calculated as ratio of tissue sodium intensity and the intensity of a vial containing a concentration of 100mmol/l.
- Skin sodium content [ Time Frame: 6 months ]Assessment of the sodium content of the calf skin. Relative sodium signal intensities were calculated as ratio of tissue sodium intensity and the intensity of a vial containing a concentration of 100mmol/l.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03505775
|University Hospital Wuerzburg, Dept. of medicine I|
|Wuerzburg, Germany, 97080|
|Principal Investigator:||Stefanie Hahner, MD, Prof.||University Hospital Wuerzburg, Dept. of medicine I, Germany|