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A New Prognostic Scoring System for Spontaneous Ruptured Hepatocellular

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ClinicalTrials.gov Identifier: NCT03504358
Recruitment Status : Completed
First Posted : April 20, 2018
Last Update Posted : April 20, 2018
Sponsor:
Information provided by (Responsible Party):
Xiaoping Chen, Huazhong University of Science and Technology

Brief Summary:
Develop a new scoring system for HCC patients with tumor rupture.

Condition or disease Intervention/treatment
Rupture, Spontaneous Procedure: Liver resection

Detailed Description:
There has been no special prognostic scoring system for HCC patients with tumor rupture in the literature. In this work, we obtained all survival risk factors of ruptured HCC patients who underwent partial hepatectomy using multivariable Cox regression analysis. Furthermore, we develop and validate a new postoperative scoring system for patients with spontaneous HCC rupture based on the these results.

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Study Type : Observational
Actual Enrollment : 129 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: A New Prognostic Scoring System for Spontaneous Ruptured Hepatocellular Carcinoma: A Retrospective Study
Actual Study Start Date : January 1, 2005
Actual Primary Completion Date : May 1, 2015
Actual Study Completion Date : December 31, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tears

Group/Cohort Intervention/treatment
Analysis before liver resection
Multivariate analysis of predictive factors associated with survival
Procedure: Liver resection
Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.

Different risk group
Low-risk group, moderate-risk group, high-risk group
Procedure: Liver resection
Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.

Model comparison
Comparison of models in predicting survival
Procedure: Liver resection
Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.




Primary Outcome Measures :
  1. Overall survival [ Time Frame: 3 years ]
    Overall survival after partial hepatectomy


Secondary Outcome Measures :
  1. Disease-free survival [ Time Frame: 3 years ]
    Recurrence-free survival after partial hepatectomy



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Ages Eligible for Study:   15 Years to 75 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
Ten year HCC rupture patients who received partial hepatectomy at Tongji Hospital of the Huazhong University of Science and Technology
Criteria

Inclusion Criteria:

  • Received partial hepatectomy; with Child A or B liver function.

Exclusion Criteria:

  • Without complete data;loss of follow-up; had reveived repeated transcatheter arterial chemoembolization before rupture; received non-radical resection.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03504358


Sponsors and Collaborators
Huazhong University of Science and Technology
Investigators
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Study Chair: Bi-xiang Zhang, Prof, PHD Huazhong University of Science and Technology

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Responsible Party: Xiaoping Chen, Professor, Huazhong University of Science and Technology
ClinicalTrials.gov Identifier: NCT03504358     History of Changes
Other Study ID Numbers: Zhupeng002
First Posted: April 20, 2018    Key Record Dates
Last Update Posted: April 20, 2018
Last Verified: April 2018

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Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Xiaoping Chen, Huazhong University of Science and Technology:
surgery
scoring system
hepatocellular carcinoma
homogeneity and discriminatory ability
survival

Additional relevant MeSH terms:
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Carcinoma, Hepatocellular
Rupture
Rupture, Spontaneous
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases
Wounds and Injuries
Pathological Conditions, Anatomical