A fMRI Study of Compressive Spinal Cord (CSM Plasticity)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03504254|
Recruitment Status : Recruiting
First Posted : April 20, 2018
Last Update Posted : April 17, 2019
|Condition or disease||Intervention/treatment|
|Orthopedic Disorder of Spine Neurologic Disorder||Diagnostic Test: MRI examination|
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Plasticity of Chronically Compressive Spinal Cord After Surgical Decompression - A fMRI Study|
|Actual Study Start Date :||January 11, 2012|
|Estimated Primary Completion Date :||May 31, 2019|
|Estimated Study Completion Date :||June 30, 2019|
A total of 50 CM patients requiring surgical decompression will be recruited. The inclusion criteria are a clinical diagnosis of CM including the signs of corticospinal lesions together with the appropriate radiographic findings. Patients with acute spinal cord injuries, prior spinal intervention or claustrophobia will be excluded.
Diagnostic Test: MRI examination
Three kinds of MRI techniques will be used in this study. These are (1) axial T1-weighted (T1WI) and T2-weighted imaging (T2WI), UTE MRI, (2) BOLD-based fMRI, and (3) diffusion tensor imaging (DTI).
- DTI indics [ Time Frame: Change between Enrollment and one year after surgery. ]The mean diffusivities and fractional anisotropy will be measured in the DTI
- fMRI connextivity [ Time Frame: Change between Enrollment and one year after surgery. ]Functional connectivity will be examined by calculating the averaged correlation coefficient of all regions of interest (ROIs) in gray matters.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03504254
|Contact: Guangsheng Li, Master||852-29740336|
|The university of Hong Kong||Recruiting|
|Hong Kong, Hong Kong|
|Contact: Guangsheng Li 852-29740336|