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Molecular Modulation of the Growth Plate

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ClinicalTrials.gov Identifier: NCT03501589
Recruitment Status : Enrolling by invitation
First Posted : April 18, 2018
Last Update Posted : April 18, 2018
Sponsor:
Information provided by (Responsible Party):
A. Noelle Larson, Mayo Clinic

Brief Summary:
The researchers are trying to identify molecular mechanisms that control growth plate mediated limb growth and identify agents that can be used to enhance or slow growth.

Condition or disease
Growth Plate Injury

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Molecular Modulation of the Growth Plate
Actual Study Start Date : October 31, 2013
Estimated Primary Completion Date : October 31, 2023
Estimated Study Completion Date : April 1, 2024



Primary Outcome Measures :
  1. RNA expression [ Time Frame: End of Study (1/2019 ]
    Measure RNA levels in growth plate tissue samples (ng/mL)


Biospecimen Retention:   Samples With DNA
Growth plate cartilage or bone removed as a normal part of surgical procedure that would otherwise be disposed of as waste tissue.


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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing surgery where growth plate cartilage or bone is removed as discarded tissue, waste, or surgical debris.
Criteria

Inclusion Criteria:

  • Skeletally immature children/adults undergoing surgical procedures where growth plate cartilage is removed as a normal part of their procedure; or patients undergoing surgical procedures where bone is removed as a normal part of their procedure.

Exclusion Criteria:

  • Skeletally mature children/adults

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03501589


Locations
United States, Minnesota
Mayo Clinic`
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: A. Noelle Larson, M.D. Mayo Clinic

Responsible Party: A. Noelle Larson, Principal Investigator, Mayo Clinic
ClinicalTrials.gov Identifier: NCT03501589     History of Changes
Other Study ID Numbers: 13-005403
First Posted: April 18, 2018    Key Record Dates
Last Update Posted: April 18, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Salter-Harris Fractures
Fracture Dislocation
Joint Dislocations
Bone Diseases
Musculoskeletal Diseases
Wounds and Injuries
Fractures, Bone